The airway microbiome in cystic fibrosis: challenges for therapy

Laura J. Gillanders, J Stuart Elborn, Deirdre F Gilpin, T. Schneiders, Michael M Tunney

Research output: Contribution to journalLiterature review

5 Citations (Scopus)

Abstract

Although cystic fibrosis pulmonary infection is polymicrobial, routine laboratory methods focus on the detection of a small number of known pathogens. Recently, the use of strict anaerobic culture techniques and molecular technologies have identified other potential pathogens including anaerobic bacteria. Determining the role of all bacteria in a complex bacterial community and how they interact is extremely important; individual bacteria may affect how the community develops, possess virulence factors, produce quorum-sensing signals, stimulate an immune response or transfer antibiotic resistance genes, which could all contribute to disease progression. There are many challenges to managing cystic fibrosis lung infection but as knowledge about the airway microbiome continues to increase, this may lead to advances in the therapeutic management of the disease.
Original languageEnglish
Pages (from-to)645-660
Number of pages16
JournalTherapy
Volume8
Issue number6
DOIs
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

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