The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres

Fan Yang, De Chen, Zhe fei Guo, Yong ming Zhang, Yi Liu, Sean Askin, Duncan Q.M. Craig, Min Zhao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Poly (d,l-lactic-co-glycolic) acid (PLGA) based microspheres have been extensively used as controlled drug release systems. However, the burst effect has been a persistent issue associated with such systems, especially for those prepared by the double emulsion technique. An effective approach to preventing the burst effect and achieving a more ideal drug release profile is to improve the drug distribution within the polymeric matrix. Therefore, it is of great importance to establish a rapid and robust tool for screening and optimizing the drug distribution during pre-formulation. Transition Temperature Microscopy (TTM), a novel nano-thermal and imaging technique, is an extension of nano-thermal analysis (nano-TA) whereby a transition temperature is detected at a localized region of a sample and then designated a color based on a particular temperature/color palette, finally resulting in a coded map based on transition temperatures detected by carrying out a series of nanoTA measurements across the surface of the sample. In this study, we investigate the feasibility of applying the aforementioned technique combined with other thermal, imaging and structural techniques for monitoring the drug microstructure and spatial distribution within bovine serum albumin (BSA) loaded and nimodipine loaded PLGA microspheres, with a view to better predicting the in vitro drug release performance.

Original languageEnglish
Pages (from-to)34-49
JournalInternational Journal of Pharmaceutics
Volume522
Issue number1-2
Early online date21 Feb 2017
DOIs
Publication statusPublished - 30 Apr 2017

Keywords

  • Bovine serum albumin
  • Controlled drug release
  • Microsphere
  • Nimodipine
  • Poly (d,l-lactic-co-glycolic) acid
  • Transition temperature microscopy

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'The application of novel nano-thermal and imaging techniques for monitoring drug microstructure and distribution within PLGA microspheres'. Together they form a unique fingerprint.

Cite this