The assessment of vascular function during dietary intervention trials in human subjects

Damian O. McCall, Michelle C. McKinley, Rebecca Noad, Pascal P. McKeown, David R. McCance, Ian S. Young, Jayne V. Woodside*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
136 Downloads (Pure)


The potential to reduce cardiovascular morbidity through dietary modification remains an area of intense clinical and scientific interest. Any putatively beneficial intervention should be tested within a randomised controlled trial which records appropriate endpoints, ideally incident CVD and death. However, the large sample sizes required for these endpoints and associated high costs mean that the majority of dietary intervention research is conducted over short periods among either healthy volunteers or those at only slightly increased risk, with investigators using a diverse range of surrogate measures to estimate arterial health in these studies. The present review identifies commonly employed techniques, discusses the relative merits of each and highlights emerging approaches.

Original languageEnglish
Pages (from-to)981-994
JournalBritish Journal of Nutrition
Issue number7
Early online date01 Jul 2011
Publication statusPublished - 14 Oct 2011

ASJC Scopus subject areas

  • Medicine(all)
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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