Abstract
Background: Controversy remains as to whether poor oral health is independently associated with gastrointestinal cancers, due to potential confounding by smoking, alcohol and poor nutrition. The aim of this study was to investigate the association between oral health conditions and gastrointestinal cancer risk.
Methods: Data from the large, prospective UK Biobank cohort, which includes n=475,766 participants, were analysed. Cox proportional hazard models were applied to estimate the relationship between gastrointestinal cancer risk and self-reported poor oral health (defined as painful gums, bleeding gums, and/or having loose teeth), adjusting for confounders.
Results: During an average 6 years of follow-up, n=4,069 gastrointestinal cancer cases were detected, of which 13% self-reported poor oral health. Overall, there was no association between self-reported poor oral health and risk of gastrointestinal cancer detected (HR 0.97, 95% CI 0.88-1.07). In site-specific analysis, an increased risk of hepatobiliary cancers was observed in those with self-reported poor oral health (HR 1.32, 95% CI 0.95-1.80), which was stronger for hepatocellular carcinoma (HR 1.75, 95% CI 1.04-2.92).
Conclusion: Overall there was no association between self-reported poor oral health and gastrointestinal cancer risk however, there was a suggestion of an increased risk of hepatobiliary cancer, specifically hepatocellular carcinoma.
Methods: Data from the large, prospective UK Biobank cohort, which includes n=475,766 participants, were analysed. Cox proportional hazard models were applied to estimate the relationship between gastrointestinal cancer risk and self-reported poor oral health (defined as painful gums, bleeding gums, and/or having loose teeth), adjusting for confounders.
Results: During an average 6 years of follow-up, n=4,069 gastrointestinal cancer cases were detected, of which 13% self-reported poor oral health. Overall, there was no association between self-reported poor oral health and risk of gastrointestinal cancer detected (HR 0.97, 95% CI 0.88-1.07). In site-specific analysis, an increased risk of hepatobiliary cancers was observed in those with self-reported poor oral health (HR 1.32, 95% CI 0.95-1.80), which was stronger for hepatocellular carcinoma (HR 1.75, 95% CI 1.04-2.92).
Conclusion: Overall there was no association between self-reported poor oral health and gastrointestinal cancer risk however, there was a suggestion of an increased risk of hepatobiliary cancer, specifically hepatocellular carcinoma.
Original language | English |
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Journal | United European Gastroenterology Journal |
Early online date | 08 Jun 2019 |
DOIs | |
Publication status | Early online date - 08 Jun 2019 |
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Dive into the research topics of 'The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: a large prospective cohort study'. Together they form a unique fingerprint.Student Theses
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The association between oral health, related bacteria and gastrointestinal cancer risk and progression
Author: Jordao, H. W. T., Dec 2020Supervisor: Coleman, H. (Supervisor), McKenna, G. (Supervisor) & Kunzmann, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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