Methods: Data from the large, prospective UK Biobank cohort, which includes n=475,766 participants, were analysed. Cox proportional hazard models were applied to estimate the relationship between gastrointestinal cancer risk and self-reported poor oral health (defined as painful gums, bleeding gums, and/or having loose teeth), adjusting for confounders.
Results: During an average 6 years of follow-up, n=4,069 gastrointestinal cancer cases were detected, of which 13% self-reported poor oral health. Overall, there was no association between self-reported poor oral health and risk of gastrointestinal cancer detected (HR 0.97, 95% CI 0.88-1.07). In site-specific analysis, an increased risk of hepatobiliary cancers was observed in those with self-reported poor oral health (HR 1.32, 95% CI 0.95-1.80), which was stronger for hepatocellular carcinoma (HR 1.75, 95% CI 1.04-2.92).
Conclusion: Overall there was no association between self-reported poor oral health and gastrointestinal cancer risk however, there was a suggestion of an increased risk of hepatobiliary cancer, specifically hepatocellular carcinoma.
The association between oral health, related bacteria and gastrointestinal cancer risk and progressionAuthor: Jordao, H. W. T., Dec 2020
Supervisor: Coleman, H. (Supervisor), McKenna, G. (Supervisor) & Kunzmann, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of PhilosophyFile