The Association Between Y Chromosome SNPs And Chronic Kidney Disease.

Research output: Contribution to conferenceAbstract

Abstract

Chronic kidney disease (CKD) is considered a major public health problem, affecting approximately 10% of the global population. While a comprehensive review of known CKD biomarkers yielded many results, it also highlighted a lack of research in chromosome Y. Single nucleotide polymorphisms (SNPs) on chromosome Y have previously been associated with a 50% increase in risk of developing coronary artery disease, a condition with close links to CKD. Therefore, Y chromosome SNPs may also impart increased risk of developing CKD. Individuals from the Genetics of Nephropathy: an International Effort (GENIE) consortium (n=791) and the Northern Ireland Cohort for the Longitudinal Study of Aging (NICOLA; n=1241) were genotyped using the Illumina HumanOmni1-Quad array and the Illumina CoreExome-24 array, respectively, to determine if any association exists between Y chromosome SNPs and CKD, or estimated glomerular filtration rate (eGFR), a measure of kidney function. However, poor coverage of chromosome Y resulted in only 3 SNPs in the GENIE cohort and 421 SNPs in the NICOLA cohort passing quality control. Association analysis of both datasets did not reveal any significant associations. Due to limitations of this study, further analysis is required to determine whether SNPs on chromosome Y are associated with CKD and/or eGFR. An array with greater Y chromosome coverage will be selected and be used to re-genotype these individuals, and individuals from additional cohorts, allowing greater SNP coverage and direct comparison of SNPs between these cohorts. Increased SNP coverage and increased participant numbers will allow meta-analysis to be performed with sufficient power.
Original languageEnglish
Publication statusPublished - 22 Jan 2019
Event21st Meeting of the Irish Society of Human Genetics - Croke Park, Dublin, Ireland
Duration: 21 Sep 201821 Sep 2018

Conference

Conference21st Meeting of the Irish Society of Human Genetics
CountryIreland
CityDublin
Period21/09/201821/09/2018

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Y Chromosome
Chronic Renal Insufficiency
Single Nucleotide Polymorphism
Glomerular Filtration Rate
Northern Ireland
Quality Control
Longitudinal Studies
Meta-Analysis
Coronary Artery Disease
Cohort Studies
Public Health
Biomarkers
Genotype
Kidney

Cite this

Anderson, K., Cañadas-Garre, M., Maxwell, A., & McKnight, A. (2019). The Association Between Y Chromosome SNPs And Chronic Kidney Disease.. Abstract from 21st Meeting of the Irish Society of Human Genetics, Dublin, Ireland.
@conference{e1c5585f007f48b99f937984f1dafaac,
title = "The Association Between Y Chromosome SNPs And Chronic Kidney Disease.",
abstract = "Chronic kidney disease (CKD) is considered a major public health problem, affecting approximately 10{\%} of the global population. While a comprehensive review of known CKD biomarkers yielded many results, it also highlighted a lack of research in chromosome Y. Single nucleotide polymorphisms (SNPs) on chromosome Y have previously been associated with a 50{\%} increase in risk of developing coronary artery disease, a condition with close links to CKD. Therefore, Y chromosome SNPs may also impart increased risk of developing CKD. Individuals from the Genetics of Nephropathy: an International Effort (GENIE) consortium (n=791) and the Northern Ireland Cohort for the Longitudinal Study of Aging (NICOLA; n=1241) were genotyped using the Illumina HumanOmni1-Quad array and the Illumina CoreExome-24 array, respectively, to determine if any association exists between Y chromosome SNPs and CKD, or estimated glomerular filtration rate (eGFR), a measure of kidney function. However, poor coverage of chromosome Y resulted in only 3 SNPs in the GENIE cohort and 421 SNPs in the NICOLA cohort passing quality control. Association analysis of both datasets did not reveal any significant associations. Due to limitations of this study, further analysis is required to determine whether SNPs on chromosome Y are associated with CKD and/or eGFR. An array with greater Y chromosome coverage will be selected and be used to re-genotype these individuals, and individuals from additional cohorts, allowing greater SNP coverage and direct comparison of SNPs between these cohorts. Increased SNP coverage and increased participant numbers will allow meta-analysis to be performed with sufficient power.",
author = "Kerry Anderson and Marisa Ca{\~n}adas-Garre and Alexander Maxwell and Amy McKnight",
year = "2019",
month = "1",
day = "22",
language = "English",
note = "21st Meeting of the Irish Society of Human Genetics ; Conference date: 21-09-2018 Through 21-09-2018",

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Anderson, K, Cañadas-Garre, M, Maxwell, A & McKnight, A 2019, 'The Association Between Y Chromosome SNPs And Chronic Kidney Disease.', 21st Meeting of the Irish Society of Human Genetics, Dublin, Ireland, 21/09/2018 - 21/09/2018.

The Association Between Y Chromosome SNPs And Chronic Kidney Disease. / Anderson, Kerry; Cañadas-Garre, Marisa; Maxwell, Alexander; McKnight, Amy.

2019. Abstract from 21st Meeting of the Irish Society of Human Genetics, Dublin, Ireland.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - The Association Between Y Chromosome SNPs And Chronic Kidney Disease.

AU - Anderson, Kerry

AU - Cañadas-Garre, Marisa

AU - Maxwell, Alexander

AU - McKnight, Amy

PY - 2019/1/22

Y1 - 2019/1/22

N2 - Chronic kidney disease (CKD) is considered a major public health problem, affecting approximately 10% of the global population. While a comprehensive review of known CKD biomarkers yielded many results, it also highlighted a lack of research in chromosome Y. Single nucleotide polymorphisms (SNPs) on chromosome Y have previously been associated with a 50% increase in risk of developing coronary artery disease, a condition with close links to CKD. Therefore, Y chromosome SNPs may also impart increased risk of developing CKD. Individuals from the Genetics of Nephropathy: an International Effort (GENIE) consortium (n=791) and the Northern Ireland Cohort for the Longitudinal Study of Aging (NICOLA; n=1241) were genotyped using the Illumina HumanOmni1-Quad array and the Illumina CoreExome-24 array, respectively, to determine if any association exists between Y chromosome SNPs and CKD, or estimated glomerular filtration rate (eGFR), a measure of kidney function. However, poor coverage of chromosome Y resulted in only 3 SNPs in the GENIE cohort and 421 SNPs in the NICOLA cohort passing quality control. Association analysis of both datasets did not reveal any significant associations. Due to limitations of this study, further analysis is required to determine whether SNPs on chromosome Y are associated with CKD and/or eGFR. An array with greater Y chromosome coverage will be selected and be used to re-genotype these individuals, and individuals from additional cohorts, allowing greater SNP coverage and direct comparison of SNPs between these cohorts. Increased SNP coverage and increased participant numbers will allow meta-analysis to be performed with sufficient power.

AB - Chronic kidney disease (CKD) is considered a major public health problem, affecting approximately 10% of the global population. While a comprehensive review of known CKD biomarkers yielded many results, it also highlighted a lack of research in chromosome Y. Single nucleotide polymorphisms (SNPs) on chromosome Y have previously been associated with a 50% increase in risk of developing coronary artery disease, a condition with close links to CKD. Therefore, Y chromosome SNPs may also impart increased risk of developing CKD. Individuals from the Genetics of Nephropathy: an International Effort (GENIE) consortium (n=791) and the Northern Ireland Cohort for the Longitudinal Study of Aging (NICOLA; n=1241) were genotyped using the Illumina HumanOmni1-Quad array and the Illumina CoreExome-24 array, respectively, to determine if any association exists between Y chromosome SNPs and CKD, or estimated glomerular filtration rate (eGFR), a measure of kidney function. However, poor coverage of chromosome Y resulted in only 3 SNPs in the GENIE cohort and 421 SNPs in the NICOLA cohort passing quality control. Association analysis of both datasets did not reveal any significant associations. Due to limitations of this study, further analysis is required to determine whether SNPs on chromosome Y are associated with CKD and/or eGFR. An array with greater Y chromosome coverage will be selected and be used to re-genotype these individuals, and individuals from additional cohorts, allowing greater SNP coverage and direct comparison of SNPs between these cohorts. Increased SNP coverage and increased participant numbers will allow meta-analysis to be performed with sufficient power.

M3 - Abstract

ER -

Anderson K, Cañadas-Garre M, Maxwell A, McKnight A. The Association Between Y Chromosome SNPs And Chronic Kidney Disease.. 2019. Abstract from 21st Meeting of the Irish Society of Human Genetics, Dublin, Ireland.