The Bacterial and Viral Agents of BRDC: Immune Evasion and Vaccine Developments

Rachael Lynda Bell, Hannah Louise Turkington, Sara Louise Cosby

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Bovine respiratory disease complex (BRDC) is a multifactorial disease of cattle which presents as bacterial and viral pneumonia. The causative agents of BRDC work in synergy to suppress the host immune response and increase the colonisation of the lower respiratory tracts by pathogenic bacteria. Environmental stress and/or viral infection predispose cattle to secondary bacterial infections via suppression of key innate and adaptive immune mechanisms. This allows bacteria to descend the respiratory tract unchallenged. BRDC is the costliest disease among feedlot cattle, and whilst vaccines exist for individual pathogens, there is still a lack of evidence for the efficacy of these vaccines and uncertainty surrounding the optimum timing of delivery. This review outlines the immunosuppressive actions of the individual pathogens involved in BRDC and highlights the key issues in the development of vaccinations against them.
Original languageEnglish
Article number337
Number of pages18
JournalVaccines
Volume9
Issue number4
Early online date01 Apr 2021
DOIs
Publication statusEarly online date - 01 Apr 2021

Keywords

  • bacterial agents
  • bovine respiratory disease complex (BRDC)
  • immune evasion
  • immunity
  • respiratory viruses
  • vaccine development

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