The biosynthesis and biological role of lipopolysaccharide O-antigens of pathogenic Yersiniae

Mikael Skurnik, José A Bengoechea

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Lipopolysaccharide (LPS) is the major component of the outer leaflet of the outer membrane of Gram-negative bacteria. The LPS molecule is composed of two biosynthetic entities: the lipid A--core and the O-polysaccharide (O-antigen). Most biological effects of LPS are due to the lipid A part, however, there is an increasing body of evidence indicating that O-antigen (O-ag) plays an important role in effective colonization of host tissues, resistance to complement-mediated killing and in the resistance to cationic antimicrobial peptides that are key elements of the innate immune system. In this review, we will discuss: (i) the work done on the genetics and biosynthesis of the O-ags in the genus Yersinia; (ii) the role of O-ag in virulence of these bacteria; (iii) the work done on regulation of the O-ag gene cluster expression and; (iv) the impact that the O-ag expression has on other bacterial surface and membrane components.
Original languageEnglish
Pages (from-to)2521-9
Number of pages9
JournalCarbohydrate Research
Volume338
Issue number23
Publication statusPublished - 2003

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