The c-MET-JAK1/2-STAT3 signalling axis is a critical mediator of drug resistance in Kras mutant colorectal cancer

Medicine and Dentistry

• Colorectal Cancer 100%
• Mutant 40%
• Programmed Cell Death 30%
• Cancer Cell 30%
• Neoplasm 30%
• Survival 30%
• Chemotherapy 20%
• Therapeutic Procedure 20%
• Microarray 20%
• Enalapril Maleate 10%
• Epidermal Growth Factor Receptor 10%
• Small Interfering RNA 10%
• Protein Tyrosine Kinase 10%
• Cytotoxic Agent 10%
• Drug Resistance 10%
• Mediator 10%
• Liver Biopsy 10%
• Tumor Progression 10%
• Analysis 10%
• Development 10%
• MEK Inhibitor 10%
• Combination Therapy 10%
• Primary Tumor 10%
• Cancer Model 10%
• Screening 10%
• Proto Oncogene 10%
• Colorectal Cancer Cell Line 10%
• Drug 10%
• Monoclonal Antibody Therapy 10%
• Metastatic Colorectal Cancer 10%
• Chemotherapeutic Agent 10%
• Drug Therapy 10%
• In Vitro 10%
• Patient 10%
• Xenograft 10%

Biochemistry, Genetics and Molecular Biology

• STAT3 70%
• RNA Interference 40%
• Cancer Cell 40%
• Mutant 40%
• Small Molecule 30%
• Survival 30%
• Apoptosis 20%
• Microarray 20%
• Janus Kinase 20%
• Small Interfering RNA 10%
• Development 10%
• Proto Oncogene 10%
• Electric Potential 10%
• Screening 10%
• Growth 10%
• Wild Type 10%
• Receptor Tyrosine Kinase 10%
• Drug Resistance 10%
• Mediator 10%
• MEK Inhibitor 10%
• Cell Death 10%