The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

Krystyna Cwiklinski; Sheila Donnelly; Orla Drysdale; Heather Jewhurst; David Smith; Carolina De Marco Verissimo; Izanara Pritsch; Sandra O'Neill; John P. Dalton; Mark W. Robinson

doi:10.1016/bs.apar.2019.01.001

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

Krystyna Cwiklinski, Sheila Donnelly, Orla Drysdale, Heather Jewhurst, David Smith, Carolina De Marco Verissimo, Izanara Pritsch, Sandra O'Neill, John P. Dalton, Mark W. Robinson^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

50 Citations (Scopus)

Abstract

Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.

Original language	English
Title of host publication	Advances in parasitology
Editors	David Rollinson, Russell Stothard
Publisher	Elsevier Academic Press
Chapter	3
Pages	113-164
Volume	104
ISBN (Print)	9780128177167
DOIs	https://doi.org/10.1016/bs.apar.2019.01.001
Publication status	Published - 25 Apr 2019

Publication series

Name
ISSN (Print)	0065-308X

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10.1016/bs.apar.2019.01.001Licence: Unspecified

Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines
Drysdale, O. (Author), Mousley, A. (Supervisor) & Dalton, J. (Supervisor), Jul 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy

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Cwiklinski, K., Donnelly, S., Drysdale, O., Jewhurst, H., Smith, D., De Marco Verissimo, C., Pritsch, I., O'Neill, S., Dalton, J. P., & Robinson, M. W. (2019). The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola. In D. Rollinson, & R. Stothard (Eds.), Advances in parasitology (Vol. 104, pp. 113-164). Elsevier Academic Press . https://doi.org/10.1016/bs.apar.2019.01.001

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abstract = "Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.",

author = "Krystyna Cwiklinski and Sheila Donnelly and Orla Drysdale and Heather Jewhurst and David Smith and {De Marco Verissimo}, Carolina and Izanara Pritsch and Sandra O'Neill and Dalton, {John P.} and Robinson, {Mark W.}",

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Cwiklinski, K, Donnelly, S, Drysdale, O, Jewhurst, H, Smith, D, De Marco Verissimo, C, Pritsch, I, O'Neill, S, Dalton, JP & Robinson, MW 2019, The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola. in D Rollinson & R Stothard (eds), Advances in parasitology. vol. 104, Elsevier Academic Press , pp. 113-164. https://doi.org/10.1016/bs.apar.2019.01.001

TY - CHAP

T1 - The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

AU - Cwiklinski, Krystyna

AU - Donnelly, Sheila

AU - Drysdale, Orla

AU - Jewhurst, Heather

AU - Smith, David

AU - De Marco Verissimo, Carolina

AU - Pritsch, Izanara

AU - O'Neill, Sandra

AU - Dalton, John P.

AU - Robinson, Mark W.

PY - 2019/4/25

Y1 - 2019/4/25

N2 - Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.

AB - Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.

U2 - 10.1016/bs.apar.2019.01.001

DO - 10.1016/bs.apar.2019.01.001

M3 - Chapter (peer-reviewed)

SN - 9780128177167

VL - 104

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EP - 164

BT - Advances in parasitology

A2 - Rollinson, David

A2 - Stothard, Russell

PB - Elsevier Academic Press

ER -

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

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Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines

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