The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics

B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Saad Ali Alshehri, Shadma Wahab, Lalitkumar K. Vora, Raghu Raj Singh Thakur, Prashant Kesharwani*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Lyotropic liquid crystals are self-assembled, non-lamellar, and mesophase nanostructured materials that have garnered significant attention as drug carriers. Cubosomes, a subtype of lyotropic liquid crystalline nanoparticles, possess three-dimensional structures that display bicontinuous cubic liquid-crystalline patterns. These patterns are formed through the self-organization of unsaturated monoglycerides (amphphilic lipids such as glyceryl monooleate or phytantriol), followed by stabilization using steric polymers (poloxamers). Owing to their bicontinuous structure and steric polymer-based stabilization, cubosomes have been demonstrated to possess greater entrapment efficiency for hydrophobic drugs compared to liposomes, while also exhibiting high stability. In the past decade, there has been significant interest in cubosomes due to their ability to deliver therapeutic and contrast agents for cancer treatment and imaging with minimal side effects, establishing them as a safe and effective approach. Concerning these advantages, the present review elaborates on the general aspects, composition, and preparation techniques of cubosomes, followed by explanations of their mechanisms of drug loading and release patterns. Furthermore, the review provides meticulous discussions on the use of cubosomes in the treatment and imaging of various types of cancer, culminating in the enumeration of patents related to cubosome-based drug delivery systems.

Original languageEnglish
Article number116894
JournalEnvironmental Research
Issue numberPart 1
Early online date16 Aug 2023
Publication statusPublished - 15 Nov 2023

Bibliographical note

Funding Information:
The authors (Saad Ali Alshehri and Shadma Wahab) extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Small group Research Project under grant number RGP.1/17/44 . The author (Prashant Kesharwani) acknowledges financial support from the Indian Council of Medical Research (ICMR), New Delhi, India, through Extramural Research Grants. Graphical abstract is created with .

Publisher Copyright:
© 2023 Elsevier Inc.


  • Cancer therapy
  • Diagnosis
  • Drug delivery
  • Lipid nanoparticles
  • Liquid crystalline nanoparticles
  • Nanomaterials

ASJC Scopus subject areas

  • Biochemistry
  • General Environmental Science


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