The developing role of receptors and adaptors

Charles Massie, Ian G Mills

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?

Original languageEnglish
Pages (from-to)403-9
Number of pages7
JournalNature Reviews. Cancer
Volume6
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Animals
  • Humans
  • Neoplasms
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Growth Factor
  • Signal Transduction

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