The developing role of receptors and adaptors

Charles Massie; Ian G Mills

doi:10.1038/nrc1882

The developing role of receptors and adaptors

Charles Massie, Ian G Mills

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?

Original language	English
Pages (from-to)	403-9
Number of pages	7
Journal	Nature Reviews. Cancer
Volume	6
Issue number	5
DOIs	https://doi.org/10.1038/nrc1882
Publication status	Published - May 2006

Keywords

Animals
Humans
Neoplasms
Receptor Protein-Tyrosine Kinases
Receptors, Growth Factor
Signal Transduction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc1882

Cite this

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KW - Neoplasms

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KW - Receptors, Growth Factor

KW - Signal Transduction

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The developing role of receptors and adaptors

Abstract

Keywords

UN SDGs

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