Abstract
The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?
| Original language | English |
|---|---|
| Pages (from-to) | 403-9 |
| Number of pages | 7 |
| Journal | Nature Reviews. Cancer |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Humans
- Neoplasms
- Receptor Protein-Tyrosine Kinases
- Receptors, Growth Factor
- Signal Transduction
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