The difficult-to-treat, therapy-resistant cough: Why are current cough treatments not working and what can we do?

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18 Citations (Scopus)

Abstract

Cough can persist despite exhaustive diagnostic and therapeutic effort and has been termed 'idiopathic' or 'unexplained' but perhaps 'difficult to treat' cough is a more appropriate description. In this article the reasons for poor treatment response are discussed. These include a lack of physician fidelity to management guidelines, patient non-adherence and the lack of effective medicines. A number of randomized controlled trials have been undertaken including low dose opiate therapy, the use of a speech pathology intervention, oral antibiotics and antidepressants. The success or otherwise of such interventions will be discussed. A number of approaches to deal with the problem of 'difficult to treat cough' will be considered.
Original languageEnglish
Pages (from-to)528-31
Number of pages4
JournalPulmonary pharmacology & therapeutics
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 2013

Bibliographical note

Copyright © 2013. Published by Elsevier Ltd.

Keywords

  • Analgesics, Opioid
  • Animals
  • Anti-Bacterial Agents
  • Antidepressive Agents
  • Antitussive Agents
  • Chronic Disease
  • Cough
  • Drug Resistance
  • Guideline Adherence
  • Humans
  • Patient Compliance
  • Practice Guidelines as Topic
  • Randomized Controlled Trials as Topic
  • Speech Therapy

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