The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence

James Burrows, M.J. McGrattan, James Johnston

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Here we report the identification of 10 human, 1 murine, and 2 rat ORFs, all of which represent additional members of the DUB/USP17 family of deubiquitinating enzymes. In addition, we demonstrate that this family constitutes part of a tandemly repeated sequence conserved throughout humans, mice, and rats. Furthermore, upon examination of the known family members we have found that the multiple genes observed, in contrast to other gene families, have arisen due to the independent expansion of an ancestral sequence within each species. This premise is further strengthened by the observation that the murine and rat genes span two exons while their human counterparts have one. These observations, in conjunction with previous work demonstrating that the DUB/USP17's are cytokine inducible and that they regulate both cell growth and survival, suggest that the DUB/USP17's are a large highly conserved family of genes that may play an important role in controlling cell fate.
Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalGenomics
Volume85(4)
Issue number4
DOIs
Publication statusPublished - Apr 2005

ASJC Scopus subject areas

  • Genetics

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