The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Phan Vu Tra My; Ha Minh Lam; Corinne N. Thompson; Hoang Le Phuc; Pham Thi Ngoc Tuyet; Ha Vinh; Nguyen Van Minh Hoang; Pham Van Minh; Nguyen Thanh Vinh; Cao Thu Thuy; Tran Thi Thu Nga; Nguyen Thi Thu Hau; Nguyen Tran Chinh; Tang Chi Thuong; Ha Manh Tuan; James I. Campbell; Archie C.A. Clements; Jeremy Farrar; Maciej F. Boni; Stephen Baker

doi:10.1016/j.meegid.2013.04.014

The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Phan Vu Tra My, Ha Minh Lam, Corinne N. Thompson, Hoang Le Phuc, Pham Thi Ngoc Tuyet, Ha Vinh, Nguyen Van Minh Hoang, Pham Van Minh, Nguyen Thanh Vinh, Cao Thu Thuy, Tran Thi Thu Nga, Nguyen Thi Thu Hau, Nguyen Tran Chinh, Tang Chi Thuong, Ha Manh Tuan, James I. Campbell, Archie C.A. Clements, Jeremy Farrar, Maciej F. Boni, Stephen Baker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.

Original language	English
Pages (from-to)	335-343
Number of pages	9
Journal	Infection, Genetics and Evolution
Volume	18
Early online date	20 Apr 2013
DOIs	https://doi.org/10.1016/j.meegid.2013.04.014
Publication status	Published - Aug 2013
Externally published	Yes

Keywords

Cluster
GII.4
Norovirus
Phylogenetic
Spatial
Temporal

ASJC Scopus subject areas

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.meegid.2013.04.014Licence: CC BY

The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam
Copyright 2013 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 2.18 MBLicence: CC BY

Cite this

Tra My, P. V., Lam, H. M., Thompson, C. N., Phuc, H. L., Tuyet, P. T. N., Vinh, H., Hoang, N. V. M., Minh, P. V., Vinh, N. T., Thuy, C. T., Nga, T. T. T., Hau, N. T. T., Chinh, N. T., Thuong, T. C., Tuan, H. M., Campbell, J. I., Clements, A. C. A., Farrar, J., Boni, M. F., & Baker, S. (2013). The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. Infection, Genetics and Evolution , 18, 335-343. https://doi.org/10.1016/j.meegid.2013.04.014

@article{9459347ea15f4cf78c10055871b881a5,

title = "The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam",

abstract = "Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.",

keywords = "Cluster, GII.4, Norovirus, Phylogenetic, Spatial, Temporal",

author = "{Tra My}, {Phan Vu} and Lam, {Ha Minh} and Thompson, {Corinne N.} and Phuc, {Hoang Le} and Tuyet, {Pham Thi Ngoc} and Ha Vinh and Hoang, {Nguyen Van Minh} and Minh, {Pham Van} and Vinh, {Nguyen Thanh} and Thuy, {Cao Thu} and Nga, {Tran Thi Thu} and Hau, {Nguyen Thi Thu} and Chinh, {Nguyen Tran} and Thuong, {Tang Chi} and Tuan, {Ha Manh} and Campbell, {James I.} and Clements, {Archie C.A.} and Jeremy Farrar and Boni, {Maciej F.} and Stephen Baker",

year = "2013",

month = aug,

doi = "10.1016/j.meegid.2013.04.014",

language = "English",

volume = "18",

pages = "335--343",

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Tra My, PV, Lam, HM, Thompson, CN, Phuc, HL, Tuyet, PTN, Vinh, H, Hoang, NVM, Minh, PV, Vinh, NT, Thuy, CT, Nga, TTT, Hau, NTT, Chinh, NT, Thuong, TC, Tuan, HM, Campbell, JI, Clements, ACA, Farrar, J, Boni, MF & Baker, S 2013, 'The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam', Infection, Genetics and Evolution , vol. 18, pp. 335-343. https://doi.org/10.1016/j.meegid.2013.04.014

TY - JOUR

T1 - The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

AU - Tra My, Phan Vu

AU - Lam, Ha Minh

AU - Thompson, Corinne N.

AU - Phuc, Hoang Le

AU - Tuyet, Pham Thi Ngoc

AU - Vinh, Ha

AU - Hoang, Nguyen Van Minh

AU - Minh, Pham Van

AU - Vinh, Nguyen Thanh

AU - Thuy, Cao Thu

AU - Nga, Tran Thi Thu

AU - Hau, Nguyen Thi Thu

AU - Chinh, Nguyen Tran

AU - Thuong, Tang Chi

AU - Tuan, Ha Manh

AU - Campbell, James I.

AU - Clements, Archie C.A.

AU - Farrar, Jeremy

AU - Boni, Maciej F.

AU - Baker, Stephen

PY - 2013/8

Y1 - 2013/8

N2 - Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.

AB - Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.

KW - Cluster

KW - GII.4

KW - Norovirus

KW - Phylogenetic

KW - Spatial

KW - Temporal

U2 - 10.1016/j.meegid.2013.04.014

DO - 10.1016/j.meegid.2013.04.014

M3 - Article

C2 - 23612321

AN - SCOPUS:84880305870

SN - 1567-1348

VL - 18

SP - 335

EP - 343

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

ER -

The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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