The effect of polymer coatings on physicochemical properties of spray-dried liposomes for nasal delivery of BSA

K. H. Chen, M. Di Sabatino, B. Albertini, N. Passerini, V. L. Kett

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
443 Downloads (Pure)

Abstract

This work describes the development of spray dried polymer coated liposomes composed of soy phosphatidylcholine (SPC) and phospholipid dimyristoyl phosphatidylglycerol (DMPG) coated with alginate, chitosan or trimethyl chitosan (TMC), that are able to penetrate through the nasal mucosa and offer enhanced penetration over uncoated liposomes when delivered as a dry powder. All the liposome formulations, loaded with BSA as model antigen, were spray-dried to obtain powder size and liposome size in a suitable range for nasal delivery. Although coating resulted in some reduction in encapsulation efficiency, levels were still maintained between 60% and 69% and the structural integrity of the entrapped protein and its release characteristics were maintained. Coating with TMC gave the best product characteristics in terms of entrapment efficiency, glass transition (Tg) and mucoadhesive strength, while penetration of nasal mucosal tissue was very encouraging when these liposomes were administered as dispersions although improved results were observed for the dry powders
Original languageEnglish
Pages (from-to)312-322
Number of pages11
JournalEuropean journal of pharmaceutical sciences
Volume50
Issue number3-4
Early online date19 Jul 2013
DOIs
Publication statusPublished - 20 Nov 2013

Bibliographical note

Impact Factor 3.0
International Collaboration

Keywords

  • Nasal; Mucosal; Liposomes; Spray-dried; Protein; Glass transition; Trimethyl chitosan

ASJC Scopus subject areas

  • Pharmaceutical Science

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