The efficacy of additives for the mitigation of aflatoxins in animal feed: a systematic review and network meta-analysis

Oluwatobi Kolawole*, Wipada Siri-Anusornsak, Awanwee Petchkongkaw, Julie Meneely, Christopher Elliott

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
55 Downloads (Pure)

Abstract

The contamination of animal feed with aflatoxins is an ongoing and growing serious issue, particularly for livestock farmers in tropical and subtropical regions. Exposure of animals to an aflatoxin-contaminated diet impairs feed efficiency and increases susceptibility to diseases, resulting in mortality, feed waste, and increased production costs. They can also be excreted in milk and thus pose a significant human health risk. This systematic review and network meta-analysis aim to compare and identify the most effective intervention to alleviate the negative impact of aflatoxins on the important livestock sector, poultry production. Eligible studies on the efficacy of feed additives to mitigate the toxic effect of aflatoxins in poultry were retrieved from different databases. Additives were classified into three categories based on their mode of action and composition: organic binder, inorganic binder, and antioxidant. Moreover, alanine transaminase (ALT), a liver enzyme, was the primary indicator. Supplementing aflatoxin-contaminated feeds with different categories of additives significantly reduces serum ALT levels (p < 0.001) compared with birds fed only a contaminated diet. Inorganic binder (P-score 0.8615) was ranked to be the most efficient in terms of counteracting the toxic effect of aflatoxins, followed by antioxidant (P-score 0.6159) and organic binder (P-score 0.5018). These findings will have significant importance for farmers, veterinarians, and animal nutrition companies when deciding which type of additives to use for mitigating exposure to aflatoxins, thus improving food security and the livelihoods of smallholder farmers in developing countries.
Original languageEnglish
Article number707
Number of pages15
JournalToxins
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 2022

Keywords

  • additives
  • aflatoxins
  • antioxidant
  • binders
  • clay minerals
  • livestock
  • mitigation
  • network meta-analysis
  • yeast cell wall

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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