The FLP-side of nematodes.

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

The central role of FMRFamide-like peptides (FLPs) in nematode motor and sensory capabilities makes FLP signalling an appealing target for new parasiticides. Accumulating evidence has revealed an astounding level of FLP sequence conservation and diversity in the phylum Nematoda, and preliminary work has begun to identify the nematode FLP receptor complement in Caenorhabditis elegans, with a view to investigating their basic biology and therapeutic potential. However, much work is needed to clarify the functional aspects of FLP signalling and how these peptides exert their effects at the organismal level. Here, we summarize our current knowledge of nematode FLP signalling.
Original languageEnglish
Pages (from-to)385-396
Number of pages12
JournalTrends in Parasitology
Volume22
Issue number8
DOIs
Publication statusPublished - Aug 2006

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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