The frequency of gastrointestinal endocrine tumours in a well-defined population--Northern Ireland 1970-1985

R G Watson, C F Johnston, M M O'Hare, J R Anderson, B G Wilson, J S Collins, J M Sloan, K D Buchanan

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Abstract

The reported incidence of gastrointestinal endocrine tumours is variable. In Northern Ireland circumstances allowing such an assessment are favourable with a central diagnostic laboratory and register established to collect data on tumours from a well-defined population of 1.5 million people. From 1970 to 1985, 368 cases were recorded of which 85 per cent were carcinoid tumours. The annual incidence of carcinoid tumours was 1.3 per 100,000 of the population and the majority occurred in the appendix (61 per cent). No patients presented with the carcinoid syndrome. The annual incidence for other tumours was 0.12 per 100,000 for insulinomas; islet cell tumours of unknown type 0.07; Zollinger-Ellison syndrome 0.05; and multiple endocrine neoplasia (MEN) 0.05. There were two cases of VIPoma, one glucagonoma, one neurotensinoma and one tumour producing ACTH. It is possible that some tumours are more uncommon than others because of difficulty in diagnosis.

Original languageEnglish
Pages (from-to)647-57
Number of pages11
JournalThe Quarterly journal of medicine
Volume72
Issue number267
Publication statusPublished - Jul 1989

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Keywords

  • Adenoma, Islet Cell
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Apudoma
  • Carcinoid Tumor
  • Child
  • Female
  • Gastrointestinal Neoplasms
  • Humans
  • Male
  • Middle Aged
  • Multiple Endocrine Neoplasia
  • Northern Ireland
  • Pancreatic Neoplasms

Cite this

Watson, R. G., Johnston, C. F., O'Hare, M. M., Anderson, J. R., Wilson, B. G., Collins, J. S., ... Buchanan, K. D. (1989). The frequency of gastrointestinal endocrine tumours in a well-defined population--Northern Ireland 1970-1985. The Quarterly journal of medicine, 72(267), 647-57.