The genetic basis of infertility in men.

S. Bhasin, Con Mallidis, K. Ma

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Subfertility in men is a heterogeneous syndrome, its pathophysiology remaining unknown in the majority of affected men. A large number of genes and loci are associated with sterility in experimental animals, but the human homologues of most of these genes have not been characterized. A British study suggested that, in a large proportion of men with idiopathic infertility, the disorder is inherited as an autosomal recessive trait; this provocative hypothesis needs confirmation. Because normal germ cell development requires the temporally and spatially co-ordinated expression of a number of gene products at the hypothalamic, pituitary and testicular levels, it is safe to predict that a large number of autosomal, as well as X- and Y-linked, genes will probably be implicated in different subsets of male subfertility.
Original languageEnglish
Pages (from-to)363-388
Number of pages26
JournalBaillière's best practice
Volume14(3)
Issue number3
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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