The impact of modulator therapy in cystic fibrosis on patterns of hospitalization related to age. Results from an analysis of US inpatient episodes 2006-2016

Nga Nguyen, Grainne Crealey, Ciaran O'Neill

Research output: Contribution to journalArticlepeer-review

Abstract

The approval and subsequent reimbursement of CFTR modulator therapies from 2012 have provided a potential "game-changing" treatment for patients with cystic fibrosis (CF), especially among younger patients. We used HCUP-NIS and HCUP-KID data in 2006, 2009, 2012 and 2016 to compare the number of admissions, hospital charges/cost, length of stay (LOS) and other clinical outcomes between inpatient admissions aged over and below 20 with CF before and after the approval of CFTR therapies. We found the number of hospitalizations with CF dropped among those aged 0-20 but increased among those aged over 20. We found the average LOS and charges/costs increased among the former and decreased among the later. These findings support the hypothesis that modulator therapies have impacted on patterns of hospital care, contributing to a reduction in the number of young people treated in hospital albeit with an increase in their complexity relative to those aged over 20.
Original languageEnglish
Pages (from-to) E114-E117
JournalJournal of Cystic Fibrosis
Volume20
Issue number6
Early online date24 Sept 2021
DOIs
Publication statusPublished - Nov 2021

Fingerprint

Dive into the research topics of 'The impact of modulator therapy in cystic fibrosis on patterns of hospitalization related to age. Results from an analysis of US inpatient episodes 2006-2016'. Together they form a unique fingerprint.

Cite this