The impact of next generation sequencing technologies on haematological research - A review

Jessica S. Black; Manuel Salto-Tellez; Ken I. Mills; Mark A. Catherwood

doi:10.1016/j.pathog.2015.05.004

The impact of next generation sequencing technologies on haematological research - A review

Jessica S. Black, Manuel Salto-Tellez, Ken I. Mills, Mark A. Catherwood^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

564 Downloads (Pure)

Abstract

Next-generation sequencing (NGS) technologies have begun to revolutionize the field of haematological malignancies through the assessment of a patient's genetic makeup with a minimal cost. Significant discoveries have already provided a unique insight into disease initiation, risk stratification and therapeutic intervention. Sequencing analysis will likely form part of the routine diagnostic testing in the future. However, a number of important issues need to be addressed for that to become a reality with regard to result interpretation, laboratory workflow, data storage and ethical issues. In this review we summarize the contribution that NGS has already made to the field of haematological malignancies. Finally, we discuss the challenges that NGS technologies will bring in relation to data storage, ethical and legal issues and laboratory validation. Despite these challenges, we predict that high-throughput DNA sequencing will redefine haematological malignancies based on individualized genomic analysis.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Pathogenesis
Volume	2
Issue number	1-2
DOIs	https://doi.org/10.1016/j.pathog.2015.05.004
Publication status	Published - 06 Jun 2015

Keywords

Diagnostics
Haematological malignancies
Next generation sequencing

ASJC Scopus subject areas

Histology
Pathology and Forensic Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pathog.2015.05.004

The impact of next generation sequencing technologies on haematological research: A review
© The authors, 2015 Published by Elsevier Ltd on behalf of The Royal College of Pathologists. This is an open access article published under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 521 KB

17 Citations
1 Article

Inter-Laboratory Evaluation of a Next-Generation Sequencing Panel for Acute Myeloid Leukemia
Haslam, K., Catherwood, M. A., Dobbin, E., Sproul, A., Langabeer, S. E. & Mills, K. I., Oct 2016, In: Molecular Diagnosis & Therapy. 20, 5, p. 457-461 5 p.
Research output: Contribution to journal › Article › peer-review

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9 Citations (Scopus)

743 Downloads (Pure)

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title = "The impact of next generation sequencing technologies on haematological research - A review",

abstract = "Next-generation sequencing (NGS) technologies have begun to revolutionize the field of haematological malignancies through the assessment of a patient's genetic makeup with a minimal cost. Significant discoveries have already provided a unique insight into disease initiation, risk stratification and therapeutic intervention. Sequencing analysis will likely form part of the routine diagnostic testing in the future. However, a number of important issues need to be addressed for that to become a reality with regard to result interpretation, laboratory workflow, data storage and ethical issues. In this review we summarize the contribution that NGS has already made to the field of haematological malignancies. Finally, we discuss the challenges that NGS technologies will bring in relation to data storage, ethical and legal issues and laboratory validation. Despite these challenges, we predict that high-throughput DNA sequencing will redefine haematological malignancies based on individualized genomic analysis.",

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AU - Salto-Tellez, Manuel

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JO - Pathogenesis

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The impact of next generation sequencing technologies on haematological research - A review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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Research output

Inter-Laboratory Evaluation of a Next-Generation Sequencing Panel for Acute Myeloid Leukemia

Cite this