The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care

Lola Loewenthal, John Busby, Ronald McDowell, Thomas Brown, Hassan Burhan, Rekha Chaudhuri, Paddy Dennison, James W Dodd, Simon Doe, Shoaib Faruqi, Robin Gore, Elfatih Idris, David J Jackson, Mitesh Patel, Thomas Pantin, Ian D Pavord, Paul E Pfeffer, David Price, Hitasha Rupani, Salman SiddiquiLiam Heaney, Andrew Menzies-Gow

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: After puberty, females are more likely to develop asthma and in a more severe form than males. The associations between asthma and sex are complex with multiple intrinsic and external factors.

Aim: To evaluate the sex differences in the characteristics and treatment of patients with severe asthma (SA) in a real-world setting.

Methods: Demographic, clinical and treatment characteristics for patients with SA in the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD) were retrospectively analysed by sex using univariable and multivariable logistic regression analyses adjusted for year, age, and hospital/practice.

Results: ,679 (60.9% female) patients from UKSAR and 18,369 patients (67.9% female) from OPCRD with SA were included. Females were more likely to be symptomatic with increased Asthma Control Questionnaire-6 (UKSAR aOR: 1.14, 95% CI: 1.09, 1.18) and RCP-3 Question scores (OPCRD aOR: 1.29: 1.13, 1.47). However, they had a higher FEV1% predicted (UKSAR 68.7% vs. 64.8%, p
Conclusions: Females had increased symptoms and were more likely to be obese despite higher FEV1% predicted and lower type-2 biomarkers with consistent and clinically important differences across both datasets.
Original languageEnglish
JournalThorax
Publication statusAccepted - 24 Nov 2023

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