The Importance of DNA methylation in Prostate Cancer development

Charles E Massie, Ian G Mills, Andy G Lynch

Research output: Contribution to journalArticle

52 Citations (Scopus)
261 Downloads (Pure)

Abstract

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesised from seventeen studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets. We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by Androgen Receptor, with a specific discussion of the mitochondria and their associations with DNA methylation.

Original languageEnglish
Number of pages15
JournalJournal of Steroid Biochemistry and Molecular Biology
DOIs
Publication statusPublished - 24 Apr 2016

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