The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker

G J Linden, S E Haworth, A P Maxwell, K V Poulton, P A Dyer, D Middleton, C R Irwin, J J Marley, P McNamee, C D Short, P S Hull, J A James

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23 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the prevalence and severity of gingival overgrowth in renal transplant recipients concomitantly treated with cyclosporin and a calcium channel blocker was associated with functional polymorphisms within the signal sequence of the transforming growth factor-(TGF)beta1 gene.
Original languageEnglish
Pages (from-to)808-814
Number of pages7
JournalJournal of Periodontology
Volume72
Issue number6
DOIs
Publication statusPublished - Jun 2001

Keywords

  • Adult
  • Age Factors
  • Alleles
  • Analysis of Variance
  • Arginine
  • Calcium Channel Blockers
  • Chi-Square Distribution
  • Codon
  • Confidence Intervals
  • Cyclosporine
  • DNA
  • Female
  • Gene Expression Regulation
  • Genotype
  • Gingival Overgrowth
  • Heterozygote
  • Homozygote
  • Humans
  • Immunosuppressive Agents
  • Kidney Transplantation
  • Leucine
  • Logistic Models
  • Male
  • Odds Ratio
  • Polymorphism, Genetic
  • Proline
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1

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