The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker

G J Linden; S E Haworth; A P Maxwell; K V Poulton; P A Dyer; D Middleton; C R Irwin; J J Marley; P McNamee; C D Short; P S Hull; J A James

doi:10.1902/jop.2001.72.6.808

The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker

G J Linden, S E Haworth, A P Maxwell, K V Poulton, P A Dyer, D Middleton, C R Irwin, J J Marley, P McNamee, C D Short, P S Hull, J A James

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the prevalence and severity of gingival overgrowth in renal transplant recipients concomitantly treated with cyclosporin and a calcium channel blocker was associated with functional polymorphisms within the signal sequence of the transforming growth factor-(TGF)beta1 gene.

Original language	English
Pages (from-to)	808-814
Number of pages	7
Journal	Journal of Periodontology
Volume	72
Issue number	6
DOIs	https://doi.org/10.1902/jop.2001.72.6.808
Publication status	Published - Jun 2001

Keywords

Adult
Age Factors
Alleles
Analysis of Variance
Arginine
Calcium Channel Blockers
Chi-Square Distribution
Codon
Confidence Intervals
Cyclosporine
DNA
Female
Gene Expression Regulation
Genotype
Gingival Overgrowth
Heterozygote
Homozygote
Humans
Immunosuppressive Agents
Kidney Transplantation
Leucine
Logistic Models
Male
Odds Ratio
Polymorphism, Genetic
Proline
Transforming Growth Factor beta
Transforming Growth Factor beta1

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Linden, G. J., Haworth, S. E., Maxwell, A. P., Poulton, K. V., Dyer, P. A., Middleton, D., Irwin, C. R., Marley, J. J., McNamee, P., Short, C. D., Hull, P. S., & James, J. A. (2001). The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker. Journal of Periodontology, 72(6), 808-814. https://doi.org/10.1902/jop.2001.72.6.808

Linden, G J ; Haworth, S E ; Maxwell, A P ; Poulton, K V ; Dyer, P A ; Middleton, D ; Irwin, C R ; Marley, J J ; McNamee, P ; Short, C D ; Hull, P S ; James, J A. / The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker. In: Journal of Periodontology. 2001 ; Vol. 72, No. 6. pp. 808-814.

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title = "The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker",

abstract = "The purpose of this study was to determine whether the prevalence and severity of gingival overgrowth in renal transplant recipients concomitantly treated with cyclosporin and a calcium channel blocker was associated with functional polymorphisms within the signal sequence of the transforming growth factor-(TGF)beta1 gene.",

keywords = "Adult, Age Factors, Alleles, Analysis of Variance, Arginine, Calcium Channel Blockers, Chi-Square Distribution, Codon, Confidence Intervals, Cyclosporine, DNA, Female, Gene Expression Regulation, Genotype, Gingival Overgrowth, Heterozygote, Homozygote, Humans, Immunosuppressive Agents, Kidney Transplantation, Leucine, Logistic Models, Male, Odds Ratio, Polymorphism, Genetic, Proline, Transforming Growth Factor beta, Transforming Growth Factor beta1",

author = "Linden, {G J} and Haworth, {S E} and Maxwell, {A P} and Poulton, {K V} and Dyer, {P A} and D Middleton and Irwin, {C R} and Marley, {J J} and P McNamee and Short, {C D} and Hull, {P S} and James, {J A}",

year = "2001",

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doi = "10.1902/jop.2001.72.6.808",

language = "English",

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Linden, GJ, Haworth, SE, Maxwell, AP, Poulton, KV, Dyer, PA, Middleton, D, Irwin, CR, Marley, JJ, McNamee, P, Short, CD, Hull, PS & James, JA 2001, 'The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker', Journal of Periodontology, vol. 72, no. 6, pp. 808-814. https://doi.org/10.1902/jop.2001.72.6.808

The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker. / Linden, G J; Haworth, S E; Maxwell, A P; Poulton, K V; Dyer, P A; Middleton, D; Irwin, C R; Marley, J J; McNamee, P; Short, C D; Hull, P S; James, J A.

In: Journal of Periodontology, Vol. 72, No. 6, 06.2001, p. 808-814.

Research output: Contribution to journal › Article › peer-review

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AU - Linden, G J

AU - Haworth, S E

AU - Maxwell, A P

AU - Poulton, K V

AU - Dyer, P A

AU - Middleton, D

AU - Irwin, C R

AU - Marley, J J

AU - McNamee, P

AU - Short, C D

AU - Hull, P S

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KW - Age Factors

KW - Alleles

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KW - Calcium Channel Blockers

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KW - Codon

KW - Confidence Intervals

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KW - Female

KW - Gene Expression Regulation

KW - Genotype

KW - Gingival Overgrowth

KW - Heterozygote

KW - Homozygote

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KW - Immunosuppressive Agents

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