The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

D.G. Smith, A.D. Gribble, David Haigh, R.J. Ife, P. Lavery, P. Skett, B.P. Slingsby, R. Stacey, R.W. Ward, A. West

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.
Original languageEnglish
Pages (from-to)3137-3142
Number of pages6
JournalBioorganic & Medicinal Chemistry Letters
Volume9(21)
Issue number21
Publication statusPublished - 01 Nov 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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