The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

D.G. Smith, A.D. Gribble, David Haigh, R.J. Ife, P. Lavery, P. Skett, B.P. Slingsby, R. Stacey, R.W. Ward, A. West

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20 Citations (Scopus)

Abstract

Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.
Original languageEnglish
Pages (from-to)3137-3142
Number of pages6
JournalBioorganic & Medicinal Chemistry Letters
Volume9(21)
Issue number21
Publication statusPublished - 01 Nov 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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    Smith, D. G., Gribble, A. D., Haigh, D., Ife, R. J., Lavery, P., Skett, P., Slingsby, B. P., Stacey, R., Ward, R. W., & West, A. (1999). The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives. Bioorganic & Medicinal Chemistry Letters, 9(21)(21), 3137-3142.