Abstract
Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.
Original language | English |
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Pages (from-to) | 3137-3142 |
Number of pages | 6 |
Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 9(21) |
Issue number | 21 |
Publication status | Published - 01 Nov 1999 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science