The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

D.G. Smith; A.D. Gribble; David Haigh; R.J. Ife; P. Lavery; P. Skett; B.P. Slingsby; R. Stacey; R.W. Ward; A. West

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

D.G. Smith
, A.D. Gribble
, David Haigh
, R.J. Ife
, P. Lavery
, P. Skett
, B.P. Slingsby
, R. Stacey
, R.W. Ward
, A. West

Research output: Contribution to journal › Article › peer-review

Abstract

Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.

Original language	English
Pages (from-to)	3137-3142
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	9(21)
Issue number	21
Publication status	Published - 01 Nov 1999

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

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title = "The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.",

abstract = "Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.",

author = "D.G. Smith and A.D. Gribble and David Haigh and R.J. Ife and P. Lavery and P. Skett and B.P. Slingsby and R. Stacey and R.W. Ward and A. West",

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T1 - The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

AU - Smith, D.G.

AU - Gribble, A.D.

AU - Haigh, David

AU - Ife, R.J.

AU - Lavery, P.

AU - Skett, P.

AU - Slingsby, B.P.

AU - Stacey, R.

AU - Ward, R.W.

AU - West, A.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.

AB - Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.

UR - https://www.scopus.com/pages/publications/0033229859

M3 - Article

C2 - 10560740

SN - 1464-3405

VL - 9(21)

SP - 3137

EP - 3142

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 21

ER -

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

Abstract

ASJC Scopus subject areas

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