The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

Jenny Moi Fong Lau; Yvonne Dombrowski

doi:10.1038/cmi.2017.61

The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

Jenny Moi Fong Lau, Yvonne Dombrowski

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is on the rise in the western world.1 The dynamic interplay between genetic susceptibility, the gut microbiome and host inflammatory reactions underlying IBD are still unclear. Shedding light onto these complex interactions in IBD, Chen et al.2 identified a key role for the negative immune regulator NLRP12 in shaping the composition of the gut microbiome and maintaining intestinal homeostasis.

Original language	English
Journal	Cellular and Molecular Immunology
Early online date	24 Jul 2017
DOIs	https://doi.org/10.1038/cmi.2017.61
Publication status	Published - 24 Jul 2017

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title = "The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity",

abstract = "Inflammatory bowel disease (IBD) is on the rise in the western world.1 The dynamic interplay between genetic susceptibility, the gut microbiome and host inflammatory reactions underlying IBD are still unclear. Shedding light onto these complex interactions in IBD, Chen et al.2 identified a key role for the negative immune regulator NLRP12 in shaping the composition of the gut microbiome and maintaining intestinal homeostasis.",

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AB - Inflammatory bowel disease (IBD) is on the rise in the western world.1 The dynamic interplay between genetic susceptibility, the gut microbiome and host inflammatory reactions underlying IBD are still unclear. Shedding light onto these complex interactions in IBD, Chen et al.2 identified a key role for the negative immune regulator NLRP12 in shaping the composition of the gut microbiome and maintaining intestinal homeostasis.

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