The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum

Hong You; Geoffrey N. Gobert; Mary G. Duke; Wenbao Zhang; Yuesheng Li; Malcolm K. Jones; Donald P. McManus

doi:10.1016/j.ijpara.2012.06.002

The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum

Hong You, Geoffrey N. Gobert, Mary G. Duke, Wenbao Zhang, Yuesheng Li, Malcolm K. Jones, Donald P. McManus^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.

Original language	English
Pages (from-to)	801-807
Number of pages	7
Journal	International Journal for Parasitology
Volume	42
Issue number	9
DOIs	https://doi.org/10.1016/j.ijpara.2012.06.002
Publication status	Published - 01 Aug 2012
Externally published	Yes

Keywords

Insulin receptor
Ligand domain
Schistosomajaponicum
Transmission blocking veterinary vaccine

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijpara.2012.06.002

Cite this

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title = "The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum",

abstract = "Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.",

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author = "Hong You and Gobert, {Geoffrey N.} and Duke, {Mary G.} and Wenbao Zhang and Yuesheng Li and Jones, {Malcolm K.} and McManus, {Donald P.}",

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doi = "10.1016/j.ijpara.2012.06.002",

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T1 - The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum

AU - You, Hong

AU - Gobert, Geoffrey N.

AU - Duke, Mary G.

AU - Zhang, Wenbao

AU - Li, Yuesheng

AU - Jones, Malcolm K.

AU - McManus, Donald P.

PY - 2012/8/1

Y1 - 2012/8/1

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AB - Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.

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KW - Ligand domain

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KW - Transmission blocking veterinary vaccine

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The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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