The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum

Hong You, Geoffrey N. Gobert, Mary G. Duke, Wenbao Zhang, Yuesheng Li, Malcolm K. Jones, Donald P. McManus*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.

Original languageEnglish
Pages (from-to)801-807
Number of pages7
JournalInternational Journal for Parasitology
Volume42
Issue number9
DOIs
Publication statusPublished - 01 Aug 2012
Externally publishedYes

Keywords

  • Insulin receptor
  • Ligand domain
  • Schistosomajaponicum
  • Transmission blocking veterinary vaccine

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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