The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia

David Craig, Dominic Hart, K. McCool, S.P. McIlroy, Peter Passmore

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The explanation for why some patients develop psychotic change in Alzheimer's disease (AD) is unclear. "Psychosis-modifier genes" may act in the setting of neurodegeneration to produce AD plus psychosis in a similar way to how genetic modulation during neurodevelopment leads to schizophrenia. Because there is increasing interest in the common disruption of cytokine pathways seen in both AD and schizophrenia, we tested the association between the functional interleukin-1beta -511 promoter polymorphism with delusions and hallucinations in AD. Significant associations between psychotic symptoms and the CC genotype (p = 0.001 - p = 0.043) and C allele (p = 0.014 vs p = 0.048) were found, thus confirming the previously noted increased risk in schizophrenia.
Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalAnnals of Neurology
Volume56
Issue number1
DOIs
Publication statusPublished - Jul 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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