Abstract
Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly reshaped during early development and differentiation. Epigenetic modification of chromatin provides the necessary plasticity for cells to respond to environmental and positional cues, and enables the maintenance of acquired information without changing the DNA sequence. The mechanisms involve, among others, chemical modifications of chromatin, changes in chromatin constituents and reconfiguration of chromatin interactions and 3D structure. New advances in genome-wide technologies have paved the way towards an integrative view of epigenome dynamics during cell state transitions, and recent findings in embryonic stem cells highlight how the interplay between different epigenetic layers reshapes the transcriptional landscape.
| Original language | English |
|---|---|
| Pages (from-to) | 643-658 |
| Number of pages | 16 |
| Journal | Nature reviews. Genetics |
| Volume | 18 |
| Issue number | 11 |
| Early online date | 12 Jul 2017 |
| DOIs | |
| Publication status | Published - 14 Aug 2017 |
| Externally published | Yes |
Keywords
- Animals
- Cell Differentiation/physiology
- Chromatin/metabolism
- Chromatin Assembly and Disassembly/physiology
- Epigenesis, Genetic/physiology
- Genome-Wide Association Study
- Human Embryonic Stem Cells/cytology
- Humans
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Yaser Atlasi
- School of Medicine, Dentistry and Biomedical Sciences - Senior Lecturer
- Patrick G Johnston Centre for Cancer Research
Person: Academic