The IQGAP-myosin light chain interaction: what is its function?

David Timson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The first members of the IQGAP family of proteins were
characterised over 15 years ago. It is now known that these molecules act
at the interface between cellular signalling pathways and the actin
cytoskeleton. They bind to a diverse range of signalling molecules –
including those involved in calcium, GTPase, kinase and growth factor
signalling. One intriguing interaction is that between mammalian
IQGAP1 and the myosin essential light chain isoform, Mlc1sa. Although
this has been demonstrated in vitro, its in vivo role is not known. Indeed,
it would be tempting to dismiss it as an experimental artefact, except for
the existence of a parallel interaction in the budding yeast,
Saccharomyces cerevisae. In this organism, the IQGAP-like protein
(Iqg1p) interacts with a myosin essential light chain (Mlc1p). This interaction is critical for the correct execution of cytokinesis. IQGAP-like
proteins also play key roles in cytokinesis in other fungi. Recent work
implicating mammalian IQGAP1 in cytokinesis may help explain the role
of the interaction in higher eukarytotes.
Original languageEnglish
Title of host publicationCytoskeleton: Cell Movement, Cytokinesis and Organelles Organization
PublisherNova Science Publishers, Inc
Pages139-148
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Projects

    R1690BBC: Biochemical Analysis of human IQGAP proteins

    Timson, D. J.

    01/08/200517/12/2019

    Project: Research

    Cite this

    Timson, D. (2010). The IQGAP-myosin light chain interaction: what is its function? In Cytoskeleton: Cell Movement, Cytokinesis and Organelles Organization (pp. 139-148). Nova Science Publishers, Inc.