Abstract
Background: It is unclear whether Legionella pneumophila possesses phospholipase C (PLC) activity and thereby generates 1,2-diacylglycerol.
Results: L. pneumophila possesses three secreted enzymes with PLC activity, PlcA, PlcB, and PlcC, and a plcABC mutant was attenuated in host killing.
Conclusion: L. pneumophila encodes three members of a novel PLC family contributing to virulence.
Significance: We determined PLC activity for L. pneumophila and defined the characteristics of a novel PLC family present in Legionella, Pseudomonas, and fungi.
Original language | English |
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Pages (from-to) | 11080-11092 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 16 |
Early online date | 01 Mar 2013 |
DOIs | |
Publication status | Published - 19 Apr 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology