The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi

Philipp Aurass, Maren Schlegel, Omar Metwally, Clare R. Harding, Gunnar N. Schroeder, Gad Frankel, Antje Flieger*

*Corresponding author for this work

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: It is unclear whether Legionella pneumophila possesses phospholipase C (PLC) activity and thereby generates 1,2-diacylglycerol. 

Results: L. pneumophila possesses three secreted enzymes with PLC activity, PlcA, PlcB, and PlcC, and a plcABC mutant was attenuated in host killing. 

Conclusion: L. pneumophila encodes three members of a novel PLC family contributing to virulence. 

Significance: We determined PLC activity for L. pneumophila and defined the characteristics of a novel PLC family present in Legionella, Pseudomonas, and fungi.

Original languageEnglish
Pages (from-to)11080-11092
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number16
Early online date01 Mar 2013
DOIs
Publication statusPublished - 19 Apr 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi'. Together they form a unique fingerprint.

Cite this