Background: It is unclear whether Legionella pneumophila possesses phospholipase C (PLC) activity and thereby generates 1,2-diacylglycerol.
Results: L. pneumophila possesses three secreted enzymes with PLC activity, PlcA, PlcB, and PlcC, and a plcABC mutant was attenuated in host killing.
Conclusion: L. pneumophila encodes three members of a novel PLC family contributing to virulence.
Significance: We determined PLC activity for L. pneumophila and defined the characteristics of a novel PLC family present in Legionella, Pseudomonas, and fungi.
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology