The mechanical and rheological characterisation of implantable medical devices formulated from binary mixtures of cellulose derivatives

G.P. Andrews, D.S. Jones, A.D. Woolfson

Research output: Contribution to journalArticle

Abstract

This study highlights the potential associated with utilising multi-component polymeric gels to formulate materials that possess unique rheological and mechanical properties. The synergistic effect* and interaction between hydroxyethylcellulose (HEC) and sodium carboxymethylcellulose (NaCMC), polymers which are commonly employed as drug delivery platforms for implantable medical devices (1), have been determined using dynamic, continuous shear and texture profile analysis. * The difference between the actual response of a binary mixture and the sum of the two components comprising the mixture Increases in polymer concentration resulted in an increase in G', G? and ?' whereas tan d decreased. Similarly, significant increases were also apparent in continuous shear and texture analysis. All binary mixtures showed positive synergy values which may suggest associative interaction between the two components.
Original languageEnglish
Pages (from-to)2571-2575
Number of pages5
JournalAntec
Volume2
Publication statusPublished - 01 Jan 2003

ASJC Scopus subject areas

  • Engineering(all)

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