The Multiple Roles of the IAP Super-family in cancer

Swati Kumar; Ciaran Fairmichael; Daniel B Longley; Richard C Turkington

doi:10.1016/j.pharmthera.2020.107610

The Multiple Roles of the IAP Super-family in cancer

Swati Kumar, Ciaran Fairmichael, Daniel B Longley, Richard C Turkington

Research output: Contribution to journal › Review article › peer-review

40 Citations (Scopus)

422 Downloads (Pure)

Abstract

The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent research has however revealed that they have extensive roles in governing numerous other cellular processes. IAPs are known to modulate ubiquitin (Ub)-dependent signaling pathways through their E3 ligase activity and influence activation of nuclear factor κB (NF-κB). In this review, we discuss the involvement of IAPs in individual hallmarks of cancer and the current status of therapies targeting these critical proteins.

Original language	English
Article number	107610
Pages (from-to)	107610
Number of pages	19
Journal	Pharmacology and Therapeutics
Volume	214
Early online date	23 Jun 2020
DOIs	https://doi.org/10.1016/j.pharmthera.2020.107610 https://doi.org/10.1016/j.pharmthera.2020.107610
Publication status	Published - Oct 2020

Bibliographical note

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pharmthera.2020.107610Licence: Unspecified
10.1016/j.pharmthera.2020.107610

The Multiple Roles of the IAP Super-family in Cancer
© 2020 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/,which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Accepted author manuscript, 980 KBLicence: CC BY-NC-ND

Proteomics and metabolomics-based identification of novel treatment strategies in pancreatic ductal adenocarcinoma
Kumar, S. (Author), Turkington, R. (Supervisor) & Kerr, E. (Supervisor), Dec 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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title = "The Multiple Roles of the IAP Super-family in cancer",

abstract = "The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent research has however revealed that they have extensive roles in governing numerous other cellular processes. IAPs are known to modulate ubiquitin (Ub)-dependent signaling pathways through their E3 ligase activity and influence activation of nuclear factor κB (NF-κB). In this review, we discuss the involvement of IAPs in individual hallmarks of cancer and the current status of therapies targeting these critical proteins.",

author = "Swati Kumar and Ciaran Fairmichael and Longley, {Daniel B} and Turkington, {Richard C}",

year = "2020",

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AU - Kumar, Swati

AU - Fairmichael, Ciaran

AU - Longley, Daniel B

AU - Turkington, Richard C

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AB - The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent research has however revealed that they have extensive roles in governing numerous other cellular processes. IAPs are known to modulate ubiquitin (Ub)-dependent signaling pathways through their E3 ligase activity and influence activation of nuclear factor κB (NF-κB). In this review, we discuss the involvement of IAPs in individual hallmarks of cancer and the current status of therapies targeting these critical proteins.

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DO - 10.1016/j.pharmthera.2020.107610

M3 - Review article

C2 - 32585232

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VL - 214

SP - 107610

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

M1 - 107610

ER -

The Multiple Roles of the IAP Super-family in cancer

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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Student theses

Proteomics and metabolomics-based identification of novel treatment strategies in pancreatic ductal adenocarcinoma

Cite this