The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Flor M. Perez-Campo; Guilherme Costa; Michael Lie-a-Ling; Valerie Kouskoff; Georges Lacaud

doi:10.1111/imm.12072

The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Flor M. Perez-Campo, Guilherme Costa, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Immunology
Volume	139
Issue number	2
DOIs	https://doi.org/10.1111/imm.12072
Publication status	Published - 23 Apr 2013

Keywords

Cancer
Epigenetics
Haematology
Stem cells

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1111/imm.12072

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abstract = "The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.",

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T1 - The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

AU - Perez-Campo, Flor M.

AU - Costa, Guilherme

AU - Lie-a-Ling, Michael

AU - Kouskoff, Valerie

AU - Lacaud, Georges

PY - 2013/4/23

Y1 - 2013/4/23

N2 - The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

AB - The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

KW - Cancer

KW - Epigenetics

KW - Haematology

KW - Stem cells

U2 - 10.1111/imm.12072

DO - 10.1111/imm.12072

M3 - Article

VL - 139

SP - 161

EP - 165

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - 2

ER -