The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Flor M. Perez-Campo, Guilherme Costa, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.
Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalImmunology
Volume139
Issue number2
DOIs
Publication statusPublished - 23 Apr 2013

Keywords

  • Cancer
  • Epigenetics
  • Haematology
  • Stem cells

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