The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

Flor M. Perez-Campo; Guilherme Costa; Michael Lie-a-Ling; Valerie Kouskoff; Georges Lacaud

doi:10.1111/imm.12072

The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

Flor M. Perez-Campo
, Guilherme Costa
, Michael Lie-a-Ling
, Valerie Kouskoff
, Georges Lacaud

Research output: Contribution to journal › Review article

49 Citations (Scopus)

Abstract

The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Immunology
Volume	139
Issue number	2
Early online date	24 Jan 2013
DOIs	https://doi.org/10.1111/imm.12072
Publication status	Published - Jun 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Epigenetics
Haematology
Stem cells

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10.1111/imm.12072

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title = "The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis",

abstract = "The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.",

keywords = "Cancer, Epigenetics, Haematology, Stem cells",

author = "Perez-Campo, \{Flor M.\} and Guilherme Costa and Michael Lie-a-Ling and Valerie Kouskoff and Georges Lacaud",

year = "2013",

month = jun,

doi = "10.1111/imm.12072",

language = "English",

volume = "139",

pages = "161--165",

journal = "Immunology",

issn = "0019-2805",

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TY - JOUR

T1 - The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

AU - Perez-Campo, Flor M.

AU - Costa, Guilherme

AU - Lie-a-Ling, Michael

AU - Kouskoff, Valerie

AU - Lacaud, Georges

PY - 2013/6

Y1 - 2013/6

N2 - The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

AB - The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

KW - Cancer

KW - Epigenetics

KW - Haematology

KW - Stem cells

U2 - 10.1111/imm.12072

DO - 10.1111/imm.12072

M3 - Review article

SN - 0019-2805

VL - 139

SP - 161

EP - 165

JO - Immunology

JF - Immunology

IS - 2

ER -

The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

Abstract

UN SDGs

Keywords

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