The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project

Traci E Clemons, Mark C Gillies, Emily Y Chew, Alan C Bird, Tunde Peto, Maria Figueroa, Molly W Harrington, Macular Telangiectasia Research Group

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


PURPOSE: To describe vision-targeted health-related quality of life (HR-QOL), measured with the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) in a cohort of patients with macular telangiectasia (MacTel) type 2 and to evaluate the relationship between visual acuity and NEI-VFQ-25 scores.

METHODS: This was an analysis of cross-sectional baseline data from a longitudinal natural history study. Patients with MacTel type 2 were enrolled in the Natural History Study of The Macular Telangiectasia Project (The MacTel Project). NEI-VFQ-25 were completed at enrollment. Linear correlation and regression analyses were used to relate baseline NEI-VFQ-25 overall and subscale scores to visual acuity.

RESULTS: Participants reported lower vision-related functioning measured by the NEI-VFQ-25 in most of the domains measured by the NEI VFQ compared with that of a normal reference group (P < 0.001 for all domains except color vision). Visual acuity was found to be associated with the NEI-VFQ-25 in many of the domains measuring degree of difficulty with common visual activities.

CONCLUSIONS: This is the first cross-sectional cohort study to assess vision targeted HR-QOL in patients with MacTel type 2. Patients with MacTel type 2 reported markedly reduced visual functioning compared to reports of a normal reference group. These findings provide support to the use of the NEI-VFQ-25 in patients with MacTel type 2 to measure the effect of disease and potential therapies on vision-targeted HR-QOL.

Original languageEnglish
Pages (from-to)4340-6
Number of pages7
JournalInvestigative ophthalmology & visual science
Issue number10
Publication statusPublished - Oct 2008


  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Health Status
  • Humans
  • Male
  • Middle Aged
  • National Institutes of Health (U.S.)
  • Ophthalmology
  • Quality of Life
  • Retinal Diseases
  • Retinal Vessels
  • Sickness Impact Profile
  • Surveys and Questionnaires
  • Telangiectasis
  • United States
  • Visual Acuity
  • Journal Article
  • Research Support, Non-U.S. Gov't


Dive into the research topics of 'The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project'. Together they form a unique fingerprint.

Cite this