The Osteogenic Potential of Brown Seaweed Extracts

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Abstract

Marine drugs hold significantly more promise than their terrestrial counterparts, which could help solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested failing to support previously reported positive effects.
Original languageEnglish
JournalMarine Drugs
DOIs
Publication statusPublished - 28 Feb 2019

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Seaweed
Complex Mixtures
Ascophyllum
Laminaria
Bone Diseases
Polyphenols
Insurance Benefits
Carotenoids
Osteoblasts
Mesenchymal Stromal Cells
Osteoporosis
Free Radicals
Cell Proliferation
fucoxanthin
Bone and Bones
Cell Line
Pharmaceutical Preparations

Cite this

@article{9be94c882f2842579e154d8693ea5341,
title = "The Osteogenic Potential of Brown Seaweed Extracts",
abstract = "Marine drugs hold significantly more promise than their terrestrial counterparts, which could help solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested failing to support previously reported positive effects.",
author = "Pamela Walsh and Susan McGrath and Steven McKelvey and Lauren Ford and Gary Sheldrake and Susan Clarke",
year = "2019",
month = "2",
day = "28",
doi = "10.3390/md17030141",
language = "English",
journal = "Marine Drugs",
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}

The Osteogenic Potential of Brown Seaweed Extracts. / Walsh, Pamela; McGrath, Susan ; McKelvey, Steven; Ford, Lauren; Sheldrake, Gary; Clarke, Susan.

In: Marine Drugs, 28.02.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Osteogenic Potential of Brown Seaweed Extracts

AU - Walsh, Pamela

AU - McGrath, Susan

AU - McKelvey, Steven

AU - Ford, Lauren

AU - Sheldrake, Gary

AU - Clarke, Susan

PY - 2019/2/28

Y1 - 2019/2/28

N2 - Marine drugs hold significantly more promise than their terrestrial counterparts, which could help solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested failing to support previously reported positive effects.

AB - Marine drugs hold significantly more promise than their terrestrial counterparts, which could help solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested failing to support previously reported positive effects.

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DO - 10.3390/md17030141

M3 - Article

JO - Marine Drugs

JF - Marine Drugs

SN - 1660-3397

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