The Osteogenic Potential of Brown Seaweeds Extracts

Aaron O'Kane, Matthew Carson, Susan Clarke, Paulo J. Gavaia, Vincent Laizé, Leonor Cancela, Gary Sheldrake, Pamela Walsh

Research output: Contribution to conferenceOther

Abstract

Brown seaweeds are evolutionarily and chemically distinct from land plants and offer significantly higher biodiversity. They produce secondary metabolites, with novel chemical signatures that cannot be found in other organisms. The osteogenic potential of compounds extracted from Ascophyllum nodosum using conventional organic solvents and green extraction technology was tested in a zebrafish system. Zebrafish exhibit a skeleton similar to humans, that can remodel (i.e. it contains osteoblasts, osteoclast and osteocytes)1. In this experiment, zebrafish larvae were used to evaluate the ability of A. nodosum extracts to stimulate opercular bone growth. The concentration of A. nodosum extracts tested ranged between 3-23 µg/ml. NMR spectroscopy and GC-MS were used to characterise the extracts. Preliminary results found that fatty acids extracts (mainly oleic and linoleic acid) which were isolated, using supercritical carbon dioxide as the extractive solvent, had the greatest osteogenic effect.

1. Montazerolghaem, M., et al. Acta Biomater. 19, 10–14(2015).
Original languageEnglish
Publication statusPublished - 10 Mar 2017
EventBIOPROSP_17: The 8th International Conference on Marine Biotechnology - UIT THE ARCTIC UNIVERSITY OF NORWAY , TROMSØ, Norway
Duration: 08 Mar 201710 Mar 2017
http://bioprosp.com/

Conference

ConferenceBIOPROSP_17
CountryNorway
CityTROMSØ
Period08/03/201710/03/2017
Internet address

Fingerprint

Phaeophyceae
Ascophyllum nodosum
Danio rerio
extracts
osteoclasts
osteoblasts
embryophytes
secondary metabolites
oleic acid
skeleton
nuclear magnetic resonance spectroscopy
linoleic acid
carbon dioxide
bones
biodiversity
fatty acids
larvae
organisms

Cite this

O'Kane, A., Carson, M., Clarke, S., Gavaia, P. J., Laizé, V., Cancela, L., ... Walsh, P. (2017). The Osteogenic Potential of Brown Seaweeds Extracts. BIOPROSP_17, TROMSØ, Norway.
O'Kane, Aaron ; Carson, Matthew ; Clarke, Susan ; Gavaia, Paulo J. ; Laizé, Vincent ; Cancela, Leonor ; Sheldrake, Gary ; Walsh, Pamela. / The Osteogenic Potential of Brown Seaweeds Extracts. BIOPROSP_17, TROMSØ, Norway.
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abstract = "Brown seaweeds are evolutionarily and chemically distinct from land plants and offer significantly higher biodiversity. They produce secondary metabolites, with novel chemical signatures that cannot be found in other organisms. The osteogenic potential of compounds extracted from Ascophyllum nodosum using conventional organic solvents and green extraction technology was tested in a zebrafish system. Zebrafish exhibit a skeleton similar to humans, that can remodel (i.e. it contains osteoblasts, osteoclast and osteocytes)1. In this experiment, zebrafish larvae were used to evaluate the ability of A. nodosum extracts to stimulate opercular bone growth. The concentration of A. nodosum extracts tested ranged between 3-23 µg/ml. NMR spectroscopy and GC-MS were used to characterise the extracts. Preliminary results found that fatty acids extracts (mainly oleic and linoleic acid) which were isolated, using supercritical carbon dioxide as the extractive solvent, had the greatest osteogenic effect.1. Montazerolghaem, M., et al. Acta Biomater. 19, 10–14(2015).",
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O'Kane, A, Carson, M, Clarke, S, Gavaia, PJ, Laizé, V, Cancela, L, Sheldrake, G & Walsh, P 2017, 'The Osteogenic Potential of Brown Seaweeds Extracts', BIOPROSP_17, TROMSØ, Norway, 08/03/2017 - 10/03/2017.

The Osteogenic Potential of Brown Seaweeds Extracts. / O'Kane, Aaron; Carson, Matthew; Clarke, Susan; Gavaia, Paulo J. ; Laizé, Vincent ; Cancela, Leonor; Sheldrake, Gary; Walsh, Pamela.

2017. BIOPROSP_17, TROMSØ, Norway.

Research output: Contribution to conferenceOther

TY - CONF

T1 - The Osteogenic Potential of Brown Seaweeds Extracts

AU - O'Kane, Aaron

AU - Carson, Matthew

AU - Clarke, Susan

AU - Gavaia, Paulo J.

AU - Laizé, Vincent

AU - Cancela, Leonor

AU - Sheldrake, Gary

AU - Walsh, Pamela

PY - 2017/3/10

Y1 - 2017/3/10

N2 - Brown seaweeds are evolutionarily and chemically distinct from land plants and offer significantly higher biodiversity. They produce secondary metabolites, with novel chemical signatures that cannot be found in other organisms. The osteogenic potential of compounds extracted from Ascophyllum nodosum using conventional organic solvents and green extraction technology was tested in a zebrafish system. Zebrafish exhibit a skeleton similar to humans, that can remodel (i.e. it contains osteoblasts, osteoclast and osteocytes)1. In this experiment, zebrafish larvae were used to evaluate the ability of A. nodosum extracts to stimulate opercular bone growth. The concentration of A. nodosum extracts tested ranged between 3-23 µg/ml. NMR spectroscopy and GC-MS were used to characterise the extracts. Preliminary results found that fatty acids extracts (mainly oleic and linoleic acid) which were isolated, using supercritical carbon dioxide as the extractive solvent, had the greatest osteogenic effect.1. Montazerolghaem, M., et al. Acta Biomater. 19, 10–14(2015).

AB - Brown seaweeds are evolutionarily and chemically distinct from land plants and offer significantly higher biodiversity. They produce secondary metabolites, with novel chemical signatures that cannot be found in other organisms. The osteogenic potential of compounds extracted from Ascophyllum nodosum using conventional organic solvents and green extraction technology was tested in a zebrafish system. Zebrafish exhibit a skeleton similar to humans, that can remodel (i.e. it contains osteoblasts, osteoclast and osteocytes)1. In this experiment, zebrafish larvae were used to evaluate the ability of A. nodosum extracts to stimulate opercular bone growth. The concentration of A. nodosum extracts tested ranged between 3-23 µg/ml. NMR spectroscopy and GC-MS were used to characterise the extracts. Preliminary results found that fatty acids extracts (mainly oleic and linoleic acid) which were isolated, using supercritical carbon dioxide as the extractive solvent, had the greatest osteogenic effect.1. Montazerolghaem, M., et al. Acta Biomater. 19, 10–14(2015).

M3 - Other

ER -

O'Kane A, Carson M, Clarke S, Gavaia PJ, Laizé V, Cancela L et al. The Osteogenic Potential of Brown Seaweeds Extracts. 2017. BIOPROSP_17, TROMSØ, Norway.