The pharmacology of nematode FMRFamide-related peptides

Aaron Maule, T.G. Geary, J.W. Bowman, C. Shaw, D W Halton, D.P. Thompson

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

FMRFamide-related peptides (FaRPs) are the largest known family of invertebrate neuropeptides. Immunocytochemical screens of nematode tissues using antisera raised to these peptides have localized extensive FaRP-immunostaining to their nervous systems. Although 21 FaRPs have been isolated and sequenced from extracts of free-living and parasitic nematodes, available evidence indicates that other FaRPs await discovery. While our knowledge of the pharmacology of these native nematode neuropeptides is extremely limited, reports on their physiological activity in nematodes are ever increasing. All the nematode FaRPs examined so far have been found to have potent and varied actions on nematode neuromuscular activity. It is only through the extensive pharmacological and physiological assessment of the tissue, cell and receptor interactions of these peptidic messengers that an understanding of their activity on nematode neuromusculature will be possible. In this review, Aaron Maule and colleagues examine the current understanding of the pharmacology of nematode FaRPs.
Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalParasitology Today
Volume12
Publication statusPublished - 1996

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