The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

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Acute myeloid leukemia (AML) is a clonal heterogeneous disease of the myeloid white blood cells. It is characterised by an accumulation of immature blast cells and a number of chromosomal and genetic mutations have been identified. In both de novo and therapy-related AML, defective DNA repair mechanisms are responsible for some of these genetic abnormalities. Targeting the DNA repair mechanism has been shown to be successful against certain forms of solid tumors and may represent a novel therapeutic approach for AML
Original languageEnglish
Pages (from-to)691-698
Number of pages8
JournalJournal of Cancer Therapy
Publication statusPublished - 28 Jul 2017

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  • Student Theses

    DNA Repair Deficincies as a Biomarker for Treatment Response in Acute Myeloid Leukaemia

    Author: Crean, C., Jul 2020

    Supervisor: Mills, K. (Supervisor), Scott, C. (Supervisor) & Prise, K. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy


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