The practical implications of using standardized estimation equations in calculating the prevalence of chronic kidney disease

Michael Quinn, A. Rainey, Karen Cairns, Adele Marshall, Gerard Savage, Frank Kee, Alexander Maxwell, Elizabeth Reaney, Damian Fogarty

Research output: Contribution to journalArticle

17 Citations (Scopus)
27 Downloads (Pure)

Abstract

Background. Kidney Disease Outcomes Quality Initiative (KDOQI) chronic kidney disease (CKD) guidelines have focused on the utility of using the modified four-variable MDRD equation (now traceable by isotope dilution mass spectrometry IDMS) in calculating estimated glomerular filtration rates (eGFRs). This study assesses the practical implications of eGFR correction equations on the range of creatinine assays currently used in the UK and further investigates the effect of these equations on the calculated prevalence of CKD in one UK region Methods. Using simulation, a range of creatinine data (30–300 µmol/l) was generated for male and female patients aged 20–100 years. The maximum differences between the IDMS and MDRD equations for all 14 UK laboratory techniques for serum creatinine measurement were explored with an average of individual eGFRs calculated according to MDRD and IDMS 30 ml/min/1.73 m2. Observed data for 93,870 patients yielded a first MDRD eGFR 3 months later of which 47 093 (71%) continued to have an eGFR
Original languageEnglish
Pages (from-to)542-548
Number of pages7
JournalNephrology Dialysis Transplantation
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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