The regulation and role of osteopontin in malignant transformation and cancer.

Mohamed El-Tanani, Frederick Campbell, V. Kurisetty, D. Jin, M. McCann, P.S. Rudland

Research output: Contribution to journalArticlepeer-review

139 Citations (Scopus)

Abstract

Osteopontin (OPN) is a predominantly secreted extracellular matrix glycophosphoprotein which binds to alpha v-containing integrins and has an important role in malignant cell attachment and invasion. High OPN expression in the primary tumor is associated with early metastasis and poor outcome in human breast and other cancers. Forced OPN overexpression in benign cells may induce neoplastic-like cell behaviour including increased attachment and invasion in vitro as well as the ability to metastasize in vivo. Conversely, OPN inhibition by antisense cDNA impedes cell growth and tumor forming capacity. OPN is not mutationally activated in cancer but its expression is regulated by Wnt/Tcf signaling, steroid receptors, growth factors, ras, Ets and AP-1 transcription factors. Presumably these factors are implicated in induction of OPN overexpression in cancer. Greater understanding of the role of OPN in neoplastic change and its transcriptional regulation may enable development of novel cancer treatment strategies
Original languageEnglish
Pages (from-to)463-474
Number of pages12
JournalCytokine
Volume17(6)
Issue number6
DOIs
Publication statusPublished - Dec 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'The regulation and role of osteopontin in malignant transformation and cancer.'. Together they form a unique fingerprint.

Cite this