The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cells

N.A. Zyuzikov, Kevin Prise, M.Z. Zdzienicka, H.C. Newman, B.D. Michael, K.R. Trott

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The RBE of alpha -particles in different mutations of Chinese hamster cells was determined with the aim of identifying differences in the sensitivity to x-ray and alpha -particle-induced DNA damage. Two parental lines of Chinese hamster cells and four radiosensitive mutants were irradiated with different single doses of x-rays and alpha -particles and clonogenic cell survival was determined. Radiosensitivity to x-rays varied by a factor of 5 between the cell strains whereas sensitivity to alpha -particle irradiation was almost identical among all strains. The RBE is only determined by the sensitivity of the cells towards x-rays. Since cells with different defects of repair or cell cycle control have different radiosensitivities, we conclude that the effects of x-ray irradiation and the RBE are mostly determined by the activity of repair processes.
Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalRadiation and Environmental Biophysics
Volume40
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Environmental Science(all)
  • Environmental Science (miscellaneous)
  • Environmental Chemistry
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy (miscellaneous)
  • Radiation

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