The RBE of alpha -particles in different mutations of Chinese hamster cells was determined with the aim of identifying differences in the sensitivity to x-ray and alpha -particle-induced DNA damage. Two parental lines of Chinese hamster cells and four radiosensitive mutants were irradiated with different single doses of x-rays and alpha -particles and clonogenic cell survival was determined. Radiosensitivity to x-rays varied by a factor of 5 between the cell strains whereas sensitivity to alpha -particle irradiation was almost identical among all strains. The RBE is only determined by the sensitivity of the cells towards x-rays. Since cells with different defects of repair or cell cycle control have different radiosensitivities, we conclude that the effects of x-ray irradiation and the RBE are mostly determined by the activity of repair processes.
|Number of pages||6|
|Journal||Radiation and Environmental Biophysics|
|Publication status||Published - 2001|
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Environmental Science(all)
- Environmental Science (miscellaneous)
- Environmental Chemistry
- Radiology Nuclear Medicine and imaging
- Physics and Astronomy (miscellaneous)
Zyuzikov, N. A., Prise, K., Zdzienicka, M. Z., Newman, H. C., Michael, B. D., & Trott, K. R. (2001). The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cells. Radiation and Environmental Biophysics, 40(3), 243-248.