The role of CaMKK2 in Golgi-associated vesicle trafficking

Grace Kennedy , Olivia Gibson, Daire T. O'Hare, Ian G. Mills, Emma Evergren*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
36 Downloads (Pure)

Abstract

Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine-protein kinase, that is involved in maintaining various physiological and cellular processes within the cell that regulate energy homeostasis and cell growth. CaMKK2 regulates glucose metabolism by the activation of downstream kinases, AMP-activated protein kinase (AMPK) and other calcium/calmodulin-dependent protein kinases. Consequently, its deregulation has a role in multiple human metabolic diseases including obesity and cancer. Despite the importance of CaMKK2, its signalling pathways and pathological mechanisms are not completely understood. Recent work has been aimed at broadening our understanding of the biological functions of CaMKK2. These studies have uncovered new interaction partners that have led to the description of new functions that include lipogenesis and Golgi vesicle trafficking. Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications in a cellular context and for disease.
Original languageEnglish
Pages (from-to)331-342
Number of pages12
JournalBiochemical Society Transactions
Volume51
Issue number1
DOIs
Publication statusPublished - 23 Feb 2023

Keywords

  • AMP-Activated Protein Kinases
  • Calcium
  • Calcium-Calmodulin-Dependent Protein Kinase Kinase
  • Calmodulin
  • Cell Proliferation
  • Golgi apparatus
  • Humans
  • Protein Serine-Threonine Kinases
  • Protein–serine–threonine Kinases
  • Signal Transduction
  • Trafficking

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