Abstract
Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine-protein kinase, that is involved in maintaining various physiological and cellular processes within the cell that regulate energy homeostasis and cell growth. CaMKK2 regulates glucose metabolism by the activation of downstream kinases, AMP-activated protein kinase (AMPK) and other calcium/calmodulin-dependent protein kinases. Consequently, its deregulation has a role in multiple human metabolic diseases including obesity and cancer. Despite the importance of CaMKK2, its signalling pathways and pathological mechanisms are not completely understood. Recent work has been aimed at broadening our understanding of the biological functions of CaMKK2. These studies have uncovered new interaction partners that have led to the description of new functions that include lipogenesis and Golgi vesicle trafficking. Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications in a cellular context and for disease.
| Original language | English |
|---|---|
| Pages (from-to) | 331-342 |
| Number of pages | 12 |
| Journal | Biochemical Society Transactions |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Feb 2023 |
Keywords
- AMP-Activated Protein Kinases
- Calcium
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Calmodulin
- Cell Proliferation
- Golgi apparatus
- Humans
- Protein Serine-Threonine Kinases
- Protein–serine–threonine Kinases
- Signal Transduction
- Trafficking
Access to Document
- The role of CaMKK2 in Golgi-associated vesicle trafficking
Copyright 2023 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.