The Role of Direct Presentation by Donor Dendritic Cells in Rejection of Minor Histocompatibility Antigen-Mismatched Skin and Hematopoietic Cell Grafts

E. Fernandes, H.D. Goold, Adrien Kissenpfennig, B. Malissen, J. Dyson, C.L. Bennett

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background. The success of transplantation is hampered by rejection of the graft by alloreactive T cells. Donor dendritic cells (DC) have been shown to be required for direct priming of immune responses to antigens from major histocompatibility complex-mismatched grafts. However, for immune responses to major histocompatibility complex-matched, minor histocompatibility (H) antigen mismatched grafts, the magnitude of the T-cell response to directly presented antigens is reduced, and the indirect pathway is more important. Therefore, we aimed to investigate the requirement for donor DC to directly present antigen from minor H antigen mismatched skin and hematopoietic grafts.
Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalTransplantation
Volume91
Issue number2
DOIs
Publication statusPublished - 27 Jan 2011

ASJC Scopus subject areas

  • Transplantation

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