The role of extracellular vesicles and gap junctions in inter-cellular mitochondrial transfer

Dayene Caldeira, Anna Krasnodembskaya*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

This chapter focuses on the mechanisms of mitochondrial transfer through extracellular vesicles (EVs) and gap junctions and the implications of such transfer to the functionality of recipient cells.

Mitochondrial donation is the efficient physiological mechanism to replace dysfunctional mitochondria and attenuate disease severity. Intercellular mitochondria transfer can occur via tunneling nanotubes and EVs, while some evidence suggests the involvement of the gap junctions. Recently, mechanisms of EV-mediated transfer of mitochondrial cargo have been clarified showing an active and selective packaging of mitochondrial proteins into EVs resulting in the blocking of mitochondrial damage and prevention of the release of proinflammatory oxidized mitochondrial content.

Formation of small vesicular carriers that transport mitochondrial proteins and lipids to other intracellular organelles and could be secreted into extracellular space (mitochondrial-derived vesicles, MDVs) will also be discussed here.

Original languageEnglish
Title of host publicationMitochondrial transplantation and transfer biology, methods, applications, and disease
EditorsGokhan Burcin Kubat, Oner Ulger, Serdar Gunaydin
PublisherElsevier Academic Press
Chapter6
Pages133-155
ISBN (Electronic)9780443188596
ISBN (Print)9780443188589
DOIs
Publication statusPublished - 09 Aug 2024

Publication series

NameTranslational and Applied Bioenergetics

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