Abstract
This chapter focuses on the mechanisms of mitochondrial transfer through extracellular vesicles (EVs) and gap junctions and the implications of such transfer to the functionality of recipient cells.
Mitochondrial donation is the efficient physiological mechanism to replace dysfunctional mitochondria and attenuate disease severity. Intercellular mitochondria transfer can occur via tunneling nanotubes and EVs, while some evidence suggests the involvement of the gap junctions. Recently, mechanisms of EV-mediated transfer of mitochondrial cargo have been clarified showing an active and selective packaging of mitochondrial proteins into EVs resulting in the blocking of mitochondrial damage and prevention of the release of proinflammatory oxidized mitochondrial content.
Formation of small vesicular carriers that transport mitochondrial proteins and lipids to other intracellular organelles and could be secreted into extracellular space (mitochondrial-derived vesicles, MDVs) will also be discussed here.
Mitochondrial donation is the efficient physiological mechanism to replace dysfunctional mitochondria and attenuate disease severity. Intercellular mitochondria transfer can occur via tunneling nanotubes and EVs, while some evidence suggests the involvement of the gap junctions. Recently, mechanisms of EV-mediated transfer of mitochondrial cargo have been clarified showing an active and selective packaging of mitochondrial proteins into EVs resulting in the blocking of mitochondrial damage and prevention of the release of proinflammatory oxidized mitochondrial content.
Formation of small vesicular carriers that transport mitochondrial proteins and lipids to other intracellular organelles and could be secreted into extracellular space (mitochondrial-derived vesicles, MDVs) will also be discussed here.
Original language | English |
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Title of host publication | Mitochondrial transplantation and transfer biology, methods, applications, and disease |
Editors | Gokhan Burcin Kubat, Oner Ulger, Serdar Gunaydin |
Publisher | Elsevier Academic Press |
Chapter | 6 |
Pages | 133-155 |
ISBN (Electronic) | 9780443188596 |
ISBN (Print) | 9780443188589 |
DOIs | |
Publication status | Published - 09 Aug 2024 |
Publication series
Name | Translational and Applied Bioenergetics |
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