The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy

T Zhou, K K Zhou, K Lee, G Gao, T J Lyons, R Kowluru, J-x Ma

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes.
Original languageEnglish
Pages (from-to)459-68
Number of pages10
JournalDiabetologia
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Acetylcysteine
  • Aldehydes
  • Animals
  • Blotting, Western
  • Cell Line
  • Connective Tissue Growth Factor
  • Diabetic Retinopathy
  • Female
  • Humans
  • Hydrogen Peroxide
  • Immunohistochemistry
  • Ketocholesterols
  • LDL-Receptor Related Proteins
  • Lipid Peroxidation
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Oxidative Stress
  • Rats
  • TCF Transcription Factors
  • beta Catenin

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