The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy

T Zhou; K K Zhou; K Lee; G Gao; T J Lyons; R Kowluru; J-x Ma

doi:10.1007/s00125-010-1943-1

The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy

T Zhou, K K Zhou, K Lee, G Gao, T J Lyons, R Kowluru, J-x Ma

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes.

Original language	English
Pages (from-to)	459-68
Number of pages	10
Journal	Diabetologia
Volume	54
Issue number	2
DOIs	https://doi.org/10.1007/s00125-010-1943-1
Publication status	Published - Feb 2011

Keywords

Acetylcysteine
Aldehydes
Animals
Blotting, Western
Cell Line
Connective Tissue Growth Factor
Diabetic Retinopathy
Female
Humans
Hydrogen Peroxide
Immunohistochemistry
Ketocholesterols
LDL-Receptor Related Proteins
Lipid Peroxidation
Low Density Lipoprotein Receptor-Related Protein-6
Oxidative Stress
Rats
TCF Transcription Factors
beta Catenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-010-1943-1

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title = "The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy",

abstract = "Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes.",

keywords = "Acetylcysteine, Aldehydes, Animals, Blotting, Western, Cell Line, Connective Tissue Growth Factor, Diabetic Retinopathy, Female, Humans, Hydrogen Peroxide, Immunohistochemistry, Ketocholesterols, LDL-Receptor Related Proteins, Lipid Peroxidation, Low Density Lipoprotein Receptor-Related Protein-6, Oxidative Stress, Rats, TCF Transcription Factors, beta Catenin",

author = "T Zhou and Zhou, {K K} and K Lee and G Gao and Lyons, {T J} and R Kowluru and J-x Ma",

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language = "English",

volume = "54",

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AU - Zhou, T

AU - Zhou, K K

AU - Lee, K

AU - Gao, G

AU - Lyons, T J

AU - Kowluru, R

AU - Ma, J-x

PY - 2011/2

Y1 - 2011/2

N2 - Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes.

AB - Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes.

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KW - Aldehydes

KW - Animals

KW - Blotting, Western

KW - Cell Line

KW - Connective Tissue Growth Factor

KW - Diabetic Retinopathy

KW - Female

KW - Humans

KW - Hydrogen Peroxide

KW - Immunohistochemistry

KW - Ketocholesterols

KW - LDL-Receptor Related Proteins

KW - Lipid Peroxidation

KW - Low Density Lipoprotein Receptor-Related Protein-6

KW - Oxidative Stress

KW - Rats

KW - TCF Transcription Factors

KW - beta Catenin

U2 - 10.1007/s00125-010-1943-1

DO - 10.1007/s00125-010-1943-1

M3 - Article

C2 - 20978740

SN - 0012-186X

VL - 54

SP - 459

EP - 468

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy

Abstract

Keywords

UN SDGs

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