The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Laura E Taggart; Stephen J McMahon; Fred J Currell; Kevin M Prise; Karl T Butterworth

doi:10.1186/s12645-014-0005-7

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Laura E Taggart, Stephen J McMahon, Fred J Currell, Kevin M Prise, Karl T Butterworth

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

347 Downloads (Pure)

Abstract

Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation.

Original language	English
Article number	PMC4164854
Number of pages	12
Journal	Cancer Nanotechnology
Volume	5
Issue number	5
Early online date	16 Sept 2014
DOIs	https://doi.org/10.1186/s12645-014-0005-7
Publication status	Published - 16 Sept 2014

Access to Document

10.1186/s12645-014-0005-7

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation
© 2014 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Final published version, 1.22 MB

Cite this

@article{41528ab1cb664979acfba63d7a0bc879,

title = "The role of mitochondrial function in gold nanoparticle mediated radiosensitisation",

abstract = "Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation.",

author = "Taggart, {Laura E} and McMahon, {Stephen J} and Currell, {Fred J} and Prise, {Kevin M} and Butterworth, {Karl T}",

year = "2014",

month = sep,

day = "16",

doi = "10.1186/s12645-014-0005-7",

language = "English",

volume = "5",

journal = "Cancer Nanotechnology",

issn = "1868-6958",

publisher = "Springer Science + Business Media",

number = "5",

}

TY - JOUR

T1 - The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

AU - Taggart, Laura E

AU - McMahon, Stephen J

AU - Currell, Fred J

AU - Prise, Kevin M

AU - Butterworth, Karl T

PY - 2014/9/16

Y1 - 2014/9/16

N2 - Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation.

AB - Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation.

U2 - 10.1186/s12645-014-0005-7

DO - 10.1186/s12645-014-0005-7

M3 - Article

C2 - 25243023

SN - 1868-6958

VL - 5

JO - Cancer Nanotechnology

JF - Cancer Nanotechnology

IS - 5

M1 - PMC4164854

ER -

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Abstract

Access to Document

Fingerprint

Cite this